A study on the immunohistochemical expression of napsin A in oral squamous cell carcinomas, intraepithelial neoplasia, and normal oral mucosa

Figures & data

Table 1. Summary of patient population (n = 70) and clinical characteristics

Clinical Characteristics	Number of patients (%)
Gender
Men	50 (71.4%)
Women	20 (28.6%)
Age years (mean, range)	61y; 32–81y
Tumor location
Tongue	26 (37.1%)
Floor of the mouth	17 (24.3%)
Retromolar area	10 (14.3%)
Tongue + floor of the mouth	5 (7.2%)
Other	12 (17.1%)
Histological Grade for OSCC
Well differentiated	29 (41.4%)
Moderately differentiated	35 (50.0%)
Poorly differentiated	6 (8.6%)
Neck lymph node metastasis
Negative	39 (55.7%)
Positive	31 (44.3%)
Distant metastases	7 (10%)
Liver	1 (1,4%)
Lung	2 (2.9%)
Multiple organs	4 (5.7%)

OSCC: Oral Squamous Cell Carcinoma

Figure 1. Immunohistochemistry assay for Napsin A expression. (a) Negative expression in healthy oral mucosa. (b) Napsin A has strong, diffuse granular cytoplasmic expression in pulmonary adenocarcinoma. (DAB) Scale bar = 400 µm

Figure 2. Immunohistochemistry assay for Napsin A expression in oral squamous cell carcinoma (OSCC). Negative expression of napsin A is seen in (a) a well-differentiated tumor and edge of the epithelium, (b) a moderately differentiated tumor, (c) a poorly differentiated tumor and (d) OSCC metastasis to neck lymph node. Scale bar = 200 µm for a, b,c. Scale bar = 50 µm for d