Preparation and Application of Ionic Liquid-Modified Stationary Phases in High Performance Liquid Chromatography

Abstract

Ionic liquid-modified stationary phases are an important class of stationary phase. They have been shown to have a capability of separating various classes of compounds in HPLC. In this review, we focus on the preparation and application of ionic liquid-modified stationary phases in HPLC. First, two common theories of retention mechanism in the ionic liquid-modified stationary phases in HPLC were discussed. Then, the preparations of two important types of stationary phase, ionic liquid-modified and poly(ionic liquids)-grafted silicas, were illustrated. Finally, applications of the ionic liquid-modified stationary phases in HPLC were reviewed, giving regard to the varieties of compounds separated or analyzed.

Keywords:

• HPLC
• ionic liquids
• stationary phase

ACKNOWLEDGEMENTS

This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education, Science, and Technology (2011-0010673).

Notes

*1–10: Mono-ionic imidazolium-modified silicas; 11–14: Zwitter-ionic imidazolium-modified silicas; 15 and 16: Long-chain imidazolium-modified silicas; 17 and 18: Poly(ionic liquids)-grafted silicas.