Microalbuminuria in patients with acute ischemic stroke

ABSTRACT

Objective: Microalbuminuria could be detected in patients with acute stroke. However, the association between microalbuminuria and the severity of ischemic stroke has not been systematically investigated. This study aimed to systematically explore the prevalence of microalbuminuria in ischemic stroke patients, and the association of microalbuminuria with the severity of ischemic stroke, as well as the prognostic value of microalbuminuria in cerebral infarction patients.

Methods: 160 ischemic stroke patients and 54 controls were enrolled and clinical characteristics were recorded. Severity of stroke was assessed by NIHSS score at admission, and outcome was measured using mRS score. The concentration of urinary microalbumin was collected for each participant. Multiple linear regression analysis was performed to evaluate the relationship between microalbuminuria and the severity of ischemic stroke, and logistic regression analysis was employed to identify the prognostic value of microalbuminuria in ischemic stroke patients.

Results: The incidence of microalbuminuria in ischemic stroke patients was 36.88%. The concentration of urinary microalbumin increased with the increasing of cerebral infarction size, and was independently correlated with NIHSS score at admission and mRS score at 3 months after onset. In multivariate logistic regression analyses, microalbuminuria was one of the independent risk factors for poor prognosis of cerebral infarction patients.

Conclusions: MAU was found in approximately one-third of patients with acute ischemic stroke. It was correlated with the severity of cerebral infarction at admission and clinical outcomes at 3 months after onset and could be used as a potential indicator of poor prognosis in ischemic stroke patients.

KEYWORDS:

• Ischemic stroke
• microalbuminuria
• neurological deficit
• prevalence
• prognosis

Acknowledgments

We would like to thank the staff of the Department of Neurosurgery and Neurology, Renmin Hospital of Wuhan University, for their technical help and support in this research.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Renmin Hospital of Wuhan University Guidance Fund [grant number RMYD2018M64].

Notes on contributors

Fei Li

Fei Li, male, Medical Doctor, Lecturer, Attending Neurosurgeon at Department of Neurosurgery, Renmin Hospital of Wuhan University.

Qian-Xue Chen

Qian-Xue Chen, male, Medical Doctor, Professor, Chief physician, Doctoral supervisor. Director of Department of Neurosurgery, Renmin Hospital of Wuhan University. Member of Chinese Medical Association Neurosurgery Committee, Director of Hubei Medical Association, Director of Hubei Medical Association Neurosurgery Committee.

Bo Peng

Bo Peng, male, Medical Doctor, Attending doctor at Department of Neurology, Renmin Hospital of Wuhan University.

Yan Chen

Yan Chen, female, Medical Doctor, Deputy chief physician at Department of Neurology, Renmin Hospital of Wuhan University.

Tao Yao

Tao Yao, male, Medical Doctor, Attending doctor at Department of Neurology, Renmin Hospital of Wuhan University.

Guan Wang

Guan Wang, male, Medical Doctor, Attending doctor at Department of Neurology, Renmin Hospital of Wuhan University.