White matter lesions are associated with obstructive sleep apnea hypopnea syndrome

ABSTRACT

Background

Study on the association of white matter lesions with obstructive sleep apnea hypopnea syndrome and its risk factors.

Methods

A recruited study with a sample of 172 patients from the department of neurology of the Third Affiliated Hospital of Southern Medical University between 2015 and 2019.

Results

According to the univariate analysis, the independent variables where P < 0.1 were included in the multivariate logistic regression model. After adjusting for confounding factors, the two-category logistic regression showed that Obstructive sleep apnea hypopnea syndrome (OSAHS) (OR = 8.347, 95%CI: 2.561 ~ 27.212, P < 0.001) were independent risk factors for WML, and that the prevalence of Cerebral white matter lesions (WML) increased with the severity of OSAHS (P = 0.002). In the non-OSAHS group, the mild OSAHS group, and the moderate-to-severe OSAHS group the apnea-hypopnea index (AHI) in the supine position was significantly higher than that in the left or right lateral position, showing a decreasing trend. The SaO2 < 90% total sleep time (TST SaO2 < 90%) showed an increasing trend, as did the body mass index. In the OSAHS severity groups, the AHI in the supine position was significantly higher than that in the left or right lateral position. Spearman correlation analysis showed that WML was positively related to AHI in the supine position (r = 0.209, P = 0.006).

Conclusions

OSAHS was an independent risk factor for WML. There was a positive relationship between WML and AHI in the supine position.

Abbreviations

AHI, apnea-hypopnea index; OSAHS, obstructive sleep apnea hypopnea syndrome; WML, white matter lesions; MRI, magnetic resonance imaging; BMI, body mass index; TSTSaO2 <90%, SaO2 <90% total sleep time; LSaO2, lowest oxygen saturation level; CI, confidence interval; OR, odds ratio

KEYWORDS:

• Obstructive sleep apnea hypopnea syndrome
• white matter lesions
• SaO2 <90% time/total sleep time
• lowest oxygen saturation level
• body mass index
• posture

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

Ethical approval was waived by the local Ethics Committee of the Third Affiliated Hospital of Southern Medical University in view of the retrospective nature of the study and all the procedures being performed were part of the routine, and the study was carried out in accordance with the Declaration of Helsinki.

Informed consent

This type of study does not require informed consent.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

Notes on contributors

Weihua Huang

Weihua Huang, master degree, graduated from Southern Medical University, now worked in Zengcheng Branch of Nanfang Hospital, Southern Medical University, No. 28, Chuangxin Avenue, Yongning Street, Zengcheng District, Guangzhou 511340. P. R. China. E-mail: [email protected]

Huanmin Li

Huanmin Li, master degree, now worked in Department of Neurology, The Third Affiliated Hospital of Southern Medical University, No. 183, Zhongshan Road West, Guangzhou 510630, P. R. China. E-mail: [email protected]

Huan Li

Huan Li, master degree, graduated from Southern Medical University, now worked in Department of Neurology, The Third Affiliated Hospital of Southern Medical University.

Tianrong Huang

Tianrong Huang, bachelor degree, now worked in Department of Neurology, The Third Affiliated Hospital of Southern Medical University.

Tianming Lü, Doctor's degree, now worked in Department of Neurology, The Third Affiliated Hospital of Southern Medical University.

Shiqi Yuan

Shiqi Yuan, master degree, now studying for a Doctor's degree in Jinan University.