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Nutrition and Cancer Volume 60, 2008 - Issue 3
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Review

The Interaction of Genetic Polymorphisms With Lifestyle Factors: Implications for the Dietary Prevention of Prostate Cancer

Eric C. Nelson Department of Urology, University of California at Davis, Sacramento, California, USA
,
Raymond L. Rodriguez Center for Excellence in Nutritional Genomics, University of California at Davis, California, USA
,
Kevin Dawson Center for Excellence in Nutritional Genomics, University of California at Davis, California, USA
,
Alfredo F. Galvez Center for Excellence in Nutritional Genomics, University of California at Davis, California, USA
&
Christopher P. Evans Department of Urology, University of California at Davis, Sacramento, California, USA
Pages 301-312 | Received 23 Apr 2007, Accepted 08 Oct 2007, Published online: 28 Apr 2008
 
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Abstract

Multiple studies of the impact of lifestyle factors on the development of prostate cancer have yielded inconsistent results. This may be due to unrecognized heterogeneity of the study populations, specifically genetic polymorphisms, which directly affect lifestyle interventions. We review some known polymorphisms and mechanisms of action as related to dietary and other lifestyle interventions and prostate cancer carcinogenesis. Further identification of genes affected by dietary/environmental changes will enable knowledgeable lifestyle interventions on an individual basis.

Notes

a Abbreviations are as follows: MnSOD, manganese superoxide dismutase; XRCC, x-ray repair cross complementing; MGMT, O-6-methylguanine-DNA methyltransferase; SULT, sulfotransferase; GSTM, gluthione S-transferase (GST) Mu; GSTT, GST Theta; UGT, urine diphosphate glucuronosyl transferase; RNAse L, ribonuclease L; CaP, prostate cancer; Arg7His, argon to histidine change in exon 7.

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