Abstract
This study was an exploratory analysis of dietary and other risk factors for primary salivary gland cancer in a population-based case-control study in Ontario, Canada. Cases were men and women diagnosed between 1995 and 1996 with a first primary cancer of the salivary gland, identified through the Ontario Cancer Registry. Controls were an age-matched random sample of the population of Ontario, identified through property assessment files. Cases ( n = 91) and controls ( n = 1897) completed a self-administered questionnaire with information on diet, smoking, height and weight, and other lifestyle and socio-demographic factors. Multivariate logistic regression was used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Among dietary variables, high relative to low intakes of alcohol (OR: 1.26; 95% CI: 0.68–2.35), fruits (OR: 1.26; 95% CI: 0.68–2.33), sweets (OR: 1.66; 95% CI: 0.85–3.25), dairy (OR: 1.41; 95% CI: 0.77–2.58), and starchy foods (OR: 1.78; 95% CI: 0.96–3.3) were associated with non-statistically significant increased risk of salivary gland cancer; whereas vegetables and meats were linked with non-statistically significant decreased risks of the disease. Among non-diet factors, male sex, obese BMI, exposure to occupational radiation, family history of cancer, and household income were suggestive of increased disease risk. Future work with larger numbers of cases are needed to further explore these associations.
Notes
∗Number of cases and controls may not add up to the total number of subjects because of missing values.
† Sum of daily consumption of apples, bananas, oranges, cantaloupe, and “other fruit.”
‡ Sum of daily consumption of tomatoes, carrots, broccoli, cabbage, spinach, squash, potatoes, sweet potatoes, and “other vegetables.”
§ Sum of daily consumption of above listed fruits and vegetables combined.
#Sum of daily consumption of cakes, cookies, doughnuts, pies, ice cream, and chocolate.
∗∗ Sum of daily consumption of chicken or turkey, beef as main dish, mixed beef, hamburger, hot dog, lunch meat, smoked meat, bacon, sausage, liver, fresh fish, and smoked fish.
†† Sum of daily consumption of whole milk, two percent milk, one percent milk, skim milk, and cheese.
‡‡ Sum of daily consumption of lentils, granola, cold cereal, cooked cereal, white bread, dark bread, rice, and pasta.