Food Intake and the Risk of Endometrial Endometrioid Adenocarcinoma in Japanese Women

Abstract

The present study examined the association between food intake and endometrial cancer restricted to endometrial endometrioid adenocarcinoma (EEA) using a case-control study in Japanese women. One hundred sixty-one cases and 380 controls who completed a questionnaire regarding demographic, lifestyle, and food frequency questionnaire were analyzed. Odds ratio (OR) between selected food intakes and EEA were calculated by logistic regression analysis. After adjustment putative confounding factors, the higher intakes of vegetables [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.26–0.83], peanuts (OR = 0.48, CI = 0.27–0.86), fish (OR = 0.52, CI = 0.29–0.93), boiled egg (OR = 0.24, CI = 0.33–0.92), instant noodles (OR = 1.94, CI = 1.12–3.34), instant food items (OR = 2.21, CI = 1.31–3.74), and deep-fried foods (OR = 2.87, CI = 1.58–5.21) were associated with a risk for EEA. The inverse association with a risk of EEA was also seen in higher intakes (g/1000 kcal) for vegetables (0.45, CI = 0.25–0.81) and fish (0.53, CI = 0.30–0.94) as compare to lower intake. Higher intake of vegetables, peanuts, fish, and boiled egg was associated with a reduced risk for EEA, whereas instant noodles, instant food items, and deep-fried foods was associated with an increased risk for EAA as compared to lower levels of intake.

ACKNOWLEDGMENTS

We thank all participants who took part in this study. This study was supported by a Grant-in-aid for Cancer Research and for the Third Term Comprehensive Ten Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan and a Grant-in-aid for Scientific Research on priority areas from the Ministry of Education, Science, Sports, and Culture, Japan. All authors directly participated in the planning, implementation, or analysis of this study. No financial or other relationship that could lead to a conflict of interest was present.