An Investigation into the Usage of Monosaccharides with GLUT1 and GLUT3 as Prognostic Indicators for Cancer

Abstract

The monosaccharides, glucose, fructose and galactose, are the most common and simplest forms of carbohydrates. The aim of this study was to determine the uptake of glucose as a potential therapeutic target agent for cancer treatment. The stability and transportation calculations of the monosaccharides were carried out in the blood phase by using the density functional theory and docking. The reactivity of monosaccharides, disaccharides and their transportation with GLUT1 and GLUT3 as prognostic indicators for cancer were investigated. The theoretical results of this study were supported by those reported in the literature and used in the prediction of the mechanisms of monosaccharides and the interpretation of their reactivities.

Disclosure statement

FG conceived and designed the research. FG contributed a new theoretical method. FG analyzed data. FG wrote the manuscript. The author read and approved the manuscript. The author has no conflict of interests and the research involves no human participants and/or animals in our article. The author read and approved the manuscript.

Additional information

Funding

This study was supported by the Scientific Research Projects Department of Kırıkkale University (BAP-2016/016).