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Nutrition and Cancer Volume 74, 2022 - Issue 3
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Articles

Genetic Susceptibility of DCC Gene in Gallbladder Cancer in Kashmir and Meta-Analysis

Manzoor Ahmad Malika Cancer Diagnostic & Research Centre (CDRC), Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, IndiaCorrespondence[email protected]
,
Subzar Ahmad Malikb Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India
,
Malik Gowharul Haqb Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India
,
Sadaf Ali Bangric Departments of Surgical Gastroenterology, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India
,
Sheikh Zahoor Ahmadd Department of Surgical Oncology, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India
,
Omar Javed Shahc Departments of Surgical Gastroenterology, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India
&
Zafar Amin Shaha Cancer Diagnostic & Research Centre (CDRC), Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India;b Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India
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Pages 947-955 | Received 31 Aug 2020, Accepted 07 Jun 2021, Published online: 14 Jul 2021
 
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Abstract

Deleted in colorectal carcinoma (DCC) A > G (rs714) is the most widely studied SNP of tumor suppressor DCC gene found to be associated with increased risk of various cancers. Therefore, the aim of present case control study was to investigate the role of DCC A > G (rs714) in gallbladder cancer (GBC) in Kashmir and to conduct a meta-analysis of DCC A > G (rs714) polymorphism to demonstrate the more accurate strength of these associations. Genotyping was done by PCR/RFLP and confirmed by sequencing in 100 GBC cases, and 150 controls. We also performed a comprehensive meta-analysis of 2223 subjects (1118 cases and 1105 controls) to evaluate the association between DCC A > G (rs714) polymorphisms and cancer. In present case control study DCC A > G (rs714) genotypes did not modulate the GBC cancer risk. Meta-analysis results showed that DCC A > G (rs714) is associated with increased overall cancer risk. DCC A > G (rs714) polymorphism conferred significant risk for cancer in dominant model but in recessive model P-value was at borderline. DCC A > G (rs714) genotype was associated with increased risk of cancer in Asians and Kashmiri population whereas no such association was observed in Europeans. The evidence in this meta-analysis supports a modest involvement of DCC A > G (rs714) tumoursupressor pathway genes in cancer susceptibility.

Acknowledgments

This work was supported by the Department of Biotechnology (DBT) Govt. of India, and Indian Council of Medical Research (ICMR), New Delhi, India.

Author Contributions

Manzoor Ahmad Malik; Conception, designed and interpretation of data. Subzar Ahmad Malik and Malik Gowharul Haq performed experiments, acquisition of data, and analyzed data. Sadaf Ali Bangri, Sheikh Zahoor Ahmad and Omar Javed Shah; provide essential clinical samples, Conception, drafting the article, and revise it critically for important intellectual content. Zafar Amin Shah; supervise and correct the paper and final approval of the version to be published.

Disclosure statement

The authors declare they have no competing interests.

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