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Perspective

Climbing the ladder from neuron to brain in Harold Atwood’s laboratory

Pages 142-146 | Received 28 Feb 2018, Accepted 27 Apr 2018, Published online: 23 May 2018

Figures & data

Figure 1. Complex membrane structure of the crayfish muscle fibers. The spine-like structures complicated voltage clamping efforts by the author. However, the observed structures may have functional significance in synaptic transmission analogous to dendritic spines in neurons. The phenomenon of ‘missing quanta’ may be attributed to the structures.

Figure 1. Complex membrane structure of the crayfish muscle fibers. The spine-like structures complicated voltage clamping efforts by the author. However, the observed structures may have functional significance in synaptic transmission analogous to dendritic spines in neurons. The phenomenon of ‘missing quanta’ may be attributed to the structures.

Figure 2. Depolarizing pulses applied through presynaptic recording electrode release barrages of quantal currents recoded by macropatch electrode (arrowheads). The technique was developed and put into use in several publications (adapted from Atwood et al., Citation1987).

Figure 2. Depolarizing pulses applied through presynaptic recording electrode release barrages of quantal currents recoded by macropatch electrode (arrowheads). The technique was developed and put into use in several publications (adapted from Atwood et al., Citation1987).

Figure 3. Dudel amplifier’ is shown in the author’s rig. The amplifier was introduced to us by Itzchak Parnas and used in collaborative experiments addressing mechanisms of quantal transmitter release.

Figure 3. ‘Dudel amplifier’ is shown in the author’s rig. The amplifier was introduced to us by Itzchak Parnas and used in collaborative experiments addressing mechanisms of quantal transmitter release.

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