The Rise and Fall of Malignant Fibrous Histiocytoma

Figures & data

Fig. 1 Prototypical microscopic appearance with a storiform growth pattern of spindle cells admixed with scattered pleomorphic cells embedded in a slightly myxoid collagenous stroma. H&E, × 10.

Fig. 2 Numerous pleomorphic cells with hyperchromatic undifferentiated nuclei are illustrated. Reactive inflammatory cells are evident in the stroma. H&E, × 10.

Fig. 3 Detail of a multinucleate pleomorphic histiofibroblast. The abundant cytoplasm contains a prominent branching RER, a Golgi complex, and some scattered lysosomes and lipid droplets. EM, × 15,400.

Fig. 4 Large, spindle-shaped, fibroblastic tumor cell containing prominent arrays of cytoplasmic vimentin filaments. EM, × 15,400.

Table Revised Classification of Malignant Fibrous Histiocytoma

Original classification	Proposed classification
Storiform–pleomorphic	Pleomorphic fibrosarcoma
MFH	Pleomorphic sarcoma, NOS
Myxoid MFH	Myxofibrosarcoma
Giant cell MFH	Giant cell fibrosarcoma
	Malignant giant cell tumor of
	soft parts