Ozonated Olive Oil Enhances the Growth of Granulation Tissue in a Mouse Model of Pressure Ulcer

Abstract

The curative effect of ozonated olive oil was evaluated using mouse models of cut wounds and pressure ulcers (decubitus or bedsores). Although ozonated olive oil did not significantly accelerate or decelerate wound contraction in either model, some histological modifications were observed. Ozonated olive oil induced blood coagulation in the hypodermis and cell infiltration in the dermis 1 day after its application. Moreover, it enhanced the formation of granulation tissue 10 days after application. These results indicate that ozonated olive oil promotes granulation tissue formation and is effective in the healing of wounds and pressure ulcers.

Keywords:

• Ozone
• Medical Applications
• Ozonated Olive Oil
• Granulation Tissue Formation
• Pressure Ulcer
• Wound Healing

ACKNOWLEDGMENTS

The authors would like to thank Dr. Yoshinori Iba and Dr. Kiyokazu Ozaki, Setsunan University, Osaka, for their technical advice and Hajime Ezoe for his technical assistance.