Proinflammatory Event of Ozonized Olive Oil in Mice

Abstract

Ozonized olive oil inhibited the swelling reaction of 2, 4-dinitrofluorobenzene-induced mouse-contact hypersensitivity, which is a model for chronic skin diseases involved in the initiation and propagation of several inflammatory processes, mainly due to type IV hypersensitivity. On the other hand, ozonized olive oil itself stimulated the development of inflammatory responses, such as vasodilation, swelling and epidermal hyperplasia. When repeatedly applied to the skin, ozonized olive oil caused hair loss at the site and contact hypersensitivity. These findings identify a new biological function for ozonized olive oil and indicate the risk of adverse effects with repeated application.

Keywords:

• Ozone
• Ozonized Olive Oil
• Triolein Triozonide
• Inflammatory Reaction
• Contact Hypersensitivity Reaction

Notes

Zamora, Z.B., R. González, D. Guanche, N. Merino, F. Hernández, S. Menéndez, Y. Alonso, and S. Schulz, “Antioxidant Mechanism is Involved in the Gastroprotective Effects of Ozonized Sunflower Oil in Ethanol-induced Ulcers in Rats”, Mediators Inflamm., 65873 Epub. (2007).