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Journal of Dispersion Science and Technology Volume 29, 2008 - Issue 6
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Original Articles

Drug-Induced Phase Transition from Cubic Phase to Vesicle

Jin Zhang Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, P. R. China
,
Liqiang Zheng Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, P. R. ChinaCorrespondence[email protected]
,
Xiangtao Bai Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, P. R. China
&
Li Yu Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, P. R. China
Pages 797-800 | Received 17 Apr 2007, Accepted 05 May 2007, Published online: 31 May 2008
 
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Abstract

The effect of caffeine on the phase behavior of aqueous dispersion of cubic phase was studied. The morphologies of the dispersed particles were observed by means of cryo-transmission electron microscopy (TEM) and the sizes of the dispersed particles were determined by dynamic light scattering (DLS). It was found that the addition of caffeine could lead to the phase transition from cubic phase to vesicle, and this might be due to the “salt out” effect of caffeine on the monoglyceride molecules in aqueous phase.

The work is supported by the National Basic Research Program (2007CB808004), National Natural Science Fund of China (50472069), and the Department of Science and Technology from Shandong Province (Z2004B02). The authors are also grateful to Prof. Heinz. Hoffmman for the measurements of the Cryo-TEM pictures.

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