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Journal of Dispersion Science and Technology Volume 30, 2009 - Issue 10
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Original Articles

Chitosan-DNA Particles for DNA Delivery: Effect of Chitosan Molecular Weight on Formation and Release Characteristics

M. C. Morán Chemistry Department, Coimbra University, Coimbra, PortugalCorrespondence[email protected]
,
T. Laranjeira Chemistry Department, Coimbra University, Coimbra, Portugal; Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Coimbra University, Coimbra, Portugal
,
A. Ribeiro Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Coimbra University, Coimbra, Portugal
,
M. G. Miguel Chemistry Department, Coimbra University, Coimbra, Portugal
&
B. Lindman Chemistry Department, Coimbra University, Coimbra, Portugal; Physical Chemistry 1, Lund University, Lund, Sweden
Pages 1494-1499 | Received 12 Jun 2008, Accepted 15 Jun 2008, Published online: 29 Oct 2009
 
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Abstract

Novel DNA-chitosan particles were prepared based on associative phase separation and interfacial diffusion. These particles formed at water/water emulsion type interfaces were characterized with respect to several properties including stability, DNA conformational state, and entrapment and release of DNA. In particular it was found that the chitosan molecular weight is a good controlling parameter.

This work was supported by grants from the Fundação para a Ciência e Tecnologia (POCTI/QUI/58689/2004 and PTDC/QUI/67962/2006) and a grant from FEDER through the Program (PTDCOCI 2010).

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