Non-Destructive Real-Time Glucose Quantification Using 5-Turn Meandered Signal Coplanar Sensor Integrated with Circular PDMS Cavity

Abstract

In this paper, the experimental demonstration in the prospective application of the novel label-free microwave-based Meandered Signal Coplanar Sensor (MSCS), for the non-destructive quantification of the glucose in aqueous solution, has been presented. The sensor has been designed by embedding 5-turn meander inductor in the signal conductor of a 50 Ω coplanar waveguide (CPW) transmission line, where the sensing area is configured with Polydimethylsiloxane (PDMS). Precursory modelling of the CPW transmission line and the meander inductor have been executed in MATLAB and further optimization has been carried out in 3D CST Microwave Studio Suite 2017 simulator. The experimentally measured magnitude and peak frequency for S₁₁ and S₂₁, respectively, showed good sensitivity of 18.42 dB/g/ml, 265.72 MHz/g/ml, 36.51 dB/g/ml and 1050 MHz/g/ml, respectively. The regression analysis with high linearity of 0.921, 0.944, 0.762, and 0.839, respectively, validated the correlation of the glucose concentration with the magnitude and peak frequency of the S-parameters.

KEYWORDS:

• Coplanar waveguide
• Glucose sensor
• Meander inductor
• Microwave biosensor
• Regression analysis

Acknowledgements

We would like to thank Dr. Shatendra Sharma and Mr. Amrish K. Gajjar, University Science Instrumentation Centre (USIC), JNU for workshop support.

Additional information

Funding

We would like to thank UGC-UPE II and UGC NON-NET Research Fellowship by University Grant Commission, DST-INSPIRE (Innovation in Science Pursuit for Inspired Research) Faculty Award Research Grant [IFA12-ENG-24] and DST-PURSE (Promotion of University Research and Scientific Excellence) by the Department of Science and Technology (DST), Government of India for the financial support to carry out this research work.

Notes on contributors

Swati Todi

Swati Todi received her BTech, MTech degrees in information and communication technology from Center for Converging Technologies, University of Rajasthan, Jaipur, India. She worked as an MTech research intern at Malaviya National Institute of Technology (MNIT), Jaipur. Currently, she is a PhD student in Microsystems Lab, School of Computer and Systems Sciences, Jawaharlal Nehru University (JNU), New Delhi, India. Her research interest includes microwave biosensors. She is a student member of IEEE.

Poonam Agarwal

Poonam Agarwal did MTech from Panjab University, Chandigarh and PhD from Indian Institute of Science, Bangalore. She worked as post-doctoral researcher at Nanyang Technological University Singapore. Currently, she is working as assistant professor in School of Computer and Systems Sciences, Jawaharlal Nehru University, New Delhi. She is DST INSPIRE Faculty awardee, by the Department of Science and Technology, Govt of India. Her main research interests are focused on unconventional polymer fabrication techniques for meso-scale electromechanical systems for phased array antenna systems, energy harvester, and microwave biosensor. E-mail: [email protected]