Meal replacements and fibre supplement as a strategy for weight loss. Proprietary PGX® meal replacement and PGX® fibre supplement in addition to a calorie-restricted diet to achieve weight loss in a clinical setting

Figures & data

Figure 1 Viscosity of PGX compared with other water-soluble polysaccharides after hydrating for 3 h.

Table 1. Characteristics of some commercially available meal replacements in Canada.

	Slimfast®	Optifast®	Slim Styles® PGX®
Serving size	per 325 ml	per 340 ml	per 340 ml
Calories (kcal)	245	225	230
Protein (g)	12	22.5	20 g
Protein source	Skimmed milk and sodium caseinate	Milk protein and sodium caseinate	Whey protein
Carbohydrate (g)	38	16.8	15
Dietary fibre (g)	0	0	4
Fat (g)	5	7.5	8
Note: Characteristics apply to the vanilla variety of each meal replacement product.

Figure 2 Overall weight change in the group compared with weight change in women.Note: The overall weight reduction and weight reduction in women observed over the 12-week period are both significant from baseline (p < 0.0001).

Table 2. Body weight, and waist and hip circumference measurements at baseline and after 12 weeks of the calorie-restricted diet with PGX® meal replacement and PGX® fibre supplement.

Test	Baseline	Week 12	Change from baseline	95% CI on change
Weight (kg)	94.09 ± 23.36	89.40 ± 23.72	−4.68 ± 3.73^∗	[−5.73, −3.68]
Waist (cm)	103.63 ± 14.99	96.52 ± 17.78	−7.11 ± 6.35^∗	[−8.89, −5.33]
Hip (cm)	118.87 ± 12.95	113.28 ± 94.74	−5.59 ± 3.58^∗	[−6.60, −4.57]
Note: Data represent mean ± SD with n = 52 participants. ^∗Significant difference from baseline (p < 0.0001). CI = confidence interval.

Table 3. Overall and women BMI scores at baseline and after 12 weeks of the calorie-restricted diet with PGX® meal replacement and PGX® fibre supplement.

Test	Baseline	Week 12	Change from baseline	95% CI on change
Overall BMI (kg/m^2)	33.8 ± 6.4	32.2 ± 7.1	−1.6 ± 1.4^∗	[−2, −1.2 ]
Women BMI (kg/m^2)	33.5 ± 6.2	32.0 ± 6.8	−1.6 ± 1.3^∗	[−2, −1.2 ]
Note: Overall BMI score data represent mean ± SD with n = 51 participants. Women BMI score data represent mean ± SD with n = 48 participants. ^∗Significant difference from baseline (p < 0.0001). CI = confidence interval.

Table 4. Body weight, waist and hip circumference measurements in women at baseline and after 12 weeks of the calorie-restricted diet with PGX® meal replacement and PGX® fibre supplement.

Test	Baseline	Week 12	Change from baseline	95% CI on change
Weight (kg)	91.63 ± 19.09	87.23 ± 19.59	−4.41 ± 3.14^∗	[−5.32, −3.59]
Waist (cm)	102.62 ± 14.22	94.99 ± 15.24	−7.62 ± 4.32^∗	[−8.89, −6.60]
Hip (cm)	118.62 ± 12.95	113.03 ± 13.72	−5.59 ± 3.30^∗	[−6.60, −4.83]
Note: Data represent mean ± SD with n = 49 participants. ^∗Significant difference from baseline (p < 0.0001). CI = confidence interval.