Figures & data
Table 1. The methods of humanization and application of some humanized antibodies.
Table 2. The sequence and length of linker in some single-chain antibodies.
Pavlinkova
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G.
,
Colcher
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D.
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B. J.
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Goel
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S. K.
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M. A.
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Anasetti
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J.
2002
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J. H.
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6992
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2006
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1243
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1257
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2006
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Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection
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5563
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5670
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M. H.
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Hong
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H. J.
2007
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Affinity maturation of an anti-hepatitis B virus PreS1 humanized antibody by phage display
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45
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528
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533
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Hwang
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J. C.
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Foote
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J.
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Methods
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42
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Pelat
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Bedouelle
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M. P.
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Thullier
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P.
2008
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Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering
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Finlay
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W. J.
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Cunningham
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O.
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Lambert
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M. A.
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Fennell
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B. J.
2009
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Affinity maturation of a humanized rat antibody for anti-RAGE therapy: Comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions
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Journal of Molecular Biology
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388
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541
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558
.
Kugler
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M.
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Stein
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C.
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M.
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Saul
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D.
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T.
2009
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147
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Riley
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C. J.
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Engelhardt
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K. P.
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J. W.
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Qi
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W.
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Zhu
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Y.
2009
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Y.
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P.
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Ke
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Zhang
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Y.
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Yu
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Q.
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Lee
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J.
2010
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A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models
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PLoS One
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R.
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V. A.
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L. A.
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Wark
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K. L.
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Dolezal
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O.
2010
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Protein Science
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299
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308
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Chiu
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Chou
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M. Y.
2011
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Wang
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F.
2011
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Polish Journal of Microbiology
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13
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17
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Liu
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D.
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C.
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Li
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C.
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Zhang
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X.
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Zhang
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B.
and
Mi
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Z.
2011
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Production and characterization of a humanized single-chain antibody against human integrin alphav beta3 protein
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Journal of Biological Chemistry
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286
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24500
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24507
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Thibodeaux
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B. A.
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Garbino
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N. C.
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N. M.
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Piper
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J.
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Schlesinger
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J. J.
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Blair
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C. D.
2012
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A humanized IgG but not IgM antibody is effective in prophylaxis and therapy of yellow fever infection in an AG129/17D-204 peripheral challenge mouse model
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Antiviral Research
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8
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Cheung
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N. K.
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Oncoimmunology
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Li
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P. C.
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Liao
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M. Y.
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Cheng
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P. C.
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Liang
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J. J.
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Liu
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I. J.
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Chiu
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C. Y.
2012
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Lorimer
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I. A.
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Keppler-Hafkemeyer
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A.
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Beers
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R. A.
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C. N.
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Bigner
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D. D.
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Pastan
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I.
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Proceedings of the National Academy of Sciences of the United States of America
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Rosenblum
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M. G.
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Cheung
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L. H.
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Liu
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Y.
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Marks
,
J. W. III.
2003
.
Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin
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Cancer Research
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Norton
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E. J.
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V. A.
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Flickinger
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C. J.
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J. C.
2001
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Human Reproduction
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Okamoto
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M.
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J.
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Chames
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P.
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Coulon
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S.
and
Baty
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D.
1998
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Improving the affinity and the fine specificity of an anti-cortisol antibody by parsimonious mutagenesis and phage display
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161
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Kobayashi
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Niwa
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T.
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Sun
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P.
2008
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Anti-estradiol-17beta single-chain Fv fragments: Generation, characterization, gene randomization, and optimized phage display
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Steroids
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M. D.
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M. C.
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Shibaguchi
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Cloning and sequencing of variable region cDNAs of a novel human monoclonal antibody to carcinoembryonic antigen, and generation of a single chain variable fragmented antibody
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McCarthy
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Hill
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A. S.
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S. L.
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