Figures & data
Figure 1. Dosing regime for dietary administration of OTA to rats over a standard two-year exposure. Until rats reached a body weight of 333 g, the mean daily dose (300 µg OTA/kg bwt) in this study (grey) was twice that of the NTP highest dose (black). Thereafter the mean daily dose was maintained at 100 µg/rat, causing a gradual convergence towards the NTP highest dose. Near the end of the study the mean daily dose was only about one third above that of the NTP. The plotted curve approximately reflects the inverse of animal weight as shown in
Figure 2. Mean body weight of experimental rats (grey) compared to controls (black).
Figure 3. Kaplan-Meier survival curve for the present experiment and for the high- and mid-doses of OTA in the NTP study.
Figure 4. Time points of discovery of renal tumours and weight of tumorous kidneys. Tumours occurred in the latter quarter of life. They were mostly carcinomas and unilateral, except in one animal where one microscopic adenoma was found in each kidney at the end-point of the experiment.
Figure 5. Illustration of the range of renal carcinomas occurring in response to continuous intake of OTA. A–C: large tumours in situ, variously showing metastatic nodules and unrelated testicular seminomas; D–E: moderate-sized tumours; F–G: small tumours located at the kidney pole; H: small tumour emerging laterally, its origin indicated below in longitudinal section showing internal disposition with the main tumorous half on the right.
