A pH-responsive asymmetric lipid vesicle as drug carrier

Abstract

In order to increase the loading efficiency of drug carriers, here we demonstrated a microfluidic method to fabricate an asymmetric vesicle, which contains trichloro(1H,1H,2H,2H-perfluoroocty-l)silane (TPS) inner leaflet and lipid outer leaflet. The asymmetric vesicle was characterised by fluorescence microscopy and Fourier transform infra-red spectrum. In vitro cytotoxicity of the vesicles carrying 5-fluorouacil (5-FU) has also been studied.

Keywords:

• Lipid
• asymmetric vesicles
• microfluidics
• self-assembly
• drug delivery

Disclosure statement

The authors report no conflict of interest. The authors alone are responsible for the content and writing of this paper.

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 21273059, 21528501, 21511130060), National Key Research and Development Programme (2016YFC0401104), State Key Laboratory of Urban Water Resource and Environment (Harbin Institute of Technology) (Grant No. 2014DX09), and Harbin Science and Technology Research Council (Grant No. 2014RFXXJ063).