Tissue physiology and the response to heat

Figures & data

Figure 1. Physiological changes induced during heating of tissue-isolated tumour preparations as a function of tumour temperature. Results show tumour blood flow (TBF), haemoglobin-oxygen (HbO₂) saturation in tumour micro-vessels, tumour oxygen availability and mean intra-tumour oxygen partial pressure (pO₂). (Adapted from [1].)

Figure 2. The effect of blood flow modifiers on the response of a C3H mammary carcinoma to heat. Tumours were locally heated at 42.5°C + drugs for up to 180 min and the tumour growth time (time taken for tumours to grow from 200–1000 mm³) calculated (left panel), with the results shown as means (+1 SE) for an average of 12 animals per group. The slope values for these curves and for similar data at other temperatures were then calculated and are shown (right panel). For both figures the results are for heat alone (○) or heating started 30 min after injecting HDZ (▴; 5 mg kg⁻¹; i.v.) or 3 h after FAA (•; 150 mg kg⁻¹; i.p.). (Adapted from [17], [28], [29] and unpublished data.)

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