Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas

Figures & data

Table I.  Tumour volume, prescribed hyperthermia dose and delivered hyperthermia dose for dogs in this study.

Initial tumour volume (cm^3)	Prescribed dose CEM43°CT90 (min)	Number of hyperthermia treatments	Overall mean T90 (°C)	Overall mean T10 (°C)	Delivered dose CEM43°CT90 (min)	Delivered dose CEM43°CT10 (min)
5	10	5	40.4	43.3	9.1	559
151	10	5	40.2	43.3	10.6	275
16	10	5	40.2	44.1	11.5	1450
80	40	4	39.5	46.0	25.1	3936
15	40	5	40.9	45.0	40.0	1770
3	40	5	41.3	43.9	39.3	312
12	40	5	41.1	44.8	39.4	1130

Figure 1. Oxygen measurements during a course of fractionated thermoradiotherapy in three dogs where 10 CEM43°CT₉₀ were prescribed. Tumour volume and total hyperthermia dose administered are given at the top of each panel. Filled squares are the oxygen measurements. The filled triangles along the abscissa represent hyperthermia treatments while the Xs represent radiation fractions. Fractional hyperthermia doses are given at the bottom of each panel. Note equality of ordinate scale in each panel. The line connecting the points is for visual reference only and does not imply that oxygenation status is known between measurements.

Figure 2. Oxygen measurements during a course of fractionated thermoradiotherapy in four dogs where 40 CEM43°CT₉₀ were prescribed. Tumour volume and total hyperthermia dose administered are given at the top of each panel. Filled squares are the oxygen measurements. The filled triangles along the abscissa represent hyperthermia treatments while the Xs represent radiation fractions. Fractional hyperthermia doses are given at the bottom of each panel. Note expanded ordinate scale for Dogs 6 and 7. The line connecting the points is for visual reference only and does not imply that oxygenation status is known between measurements.