Feasibility study of postoperative intraperitoneal hyperthermochemotherapy by radiofrequency capacitive heating system for advanced gastric cancer with peritoneal seeding

Figures & data

Table I.  Clinicopathologic features of patients.

	PIHC	Control
	(n = 10)	(n = 10)	P value
Age	57 ± 2.2	61 ± 2.8	0.24
Sex (male/female)	6/4	6/4	0.99
Performance status (0/1)	8/2	9/1	0.53
TMN classification
T2	0	1	0.17
T3	10	7
T4	0	2
N0	2	1	0.55
N1	1	2
N2	6	4
N3	1	3
Peritoneal seeding			0.79
Granulation	8	8
Cytologic examination	6	8
Size of main tumor (cm)	7.5 ± 1.8	9.0 ± 1.2	0.50
Type of histology			0.99
Differentiated	1	1
Undifferentiated	9	9
Type of surgery			0.53
Distal gastrectomy	1	2
Total gastrectomy	9	8

Granulation: Peritoneal seeding of gastric carcinoma proven by biopsy of abdominal granulation at laparotomy. Cytologic examination: Intraperitoneal free cancer cells detected by intraperitoneal cytologic examination with peritoneal lavage at laparotomy.

Figure 1. (a) Two infusion catheters that were placed beneath the hemidiaphragma and in the Douglas pouch for infusion and drainage. (b) Thermotron RF-8, 8 MHz radiofrequency (RF) capacitive heating equipment. In general, two opposing 25 cm diameter electrodes were selected for heating. To prevent surface burning, a cooling pad was used during hyperthermia through which 0.9% saline cooled to 5°C was circulated.

Figure 2. Typical time course of the temperature (°C) in the abdominal cavity and RF power in watts.

Figure 3. Cumulative survival of gastric cancer patients in this study (the relationship between survival months and cumulative survival rate using the Kaplan-Meyer method). Survival was computed from the initial surgery performed at our institution.

Figure 4. Progression-free survival curves of patients with or without PIHC. P = 0.074 (log rank test).

Figure 5. Overall survival curves of patients with or without PIHC. P = 0.044 (log rank test).