Magnetic silica nanocomposites for magnetic hyperthermia applications

Figures & data

Figure 1. Scheme of the apparatus for magnetic heating experiments for in vitro or in vivo applications: (1) Water-cooled exciting coil generating magnetic field; (2) Thermal insulating polystyrene foam; (3) Plastic tube for sample; (4) Fibre optic temperature probe; (5) Temperature register.

Figure 2. Some applications of magnetic nanocomposites.

Figure 3. Different magnetic cores used in core/shell structure of silica nanocomposites.

Table 1. Magnetic silica nanocomposites used in cellular and in vivo tests.

Type of nanocomposite	Size (nm)	Cargo	In vitro cell line	Animal	Magnetic field	Frequency(kHz)	Temperature (°C)	SAR (Wg^−1)	Ref.
Fe3O4-polymer core/silica shell with atherosclerotic plaque-specific peptide-1 (AP-1) as targeting ligand	50	DOX	CT26-IL4Rα	CT26 tumour bearing BALB/c mice	8^e	50–100	50 (bulk solution)	–	[63]
In situ forming implants (ISFI) entrapssuperparamagnetic iron oxide nanoparticle (SPION) embedded in silica microparticles	900	–	–	Co112 colon carcinoma cells bearing nude mice	12^c	141	47.8 (Tumourtemperature)	18	[91]
Biphasic suspension of mesoporous silicaencapsulated with YVO4:Eu3C and Fe3O4	∼100	DOX	HeLa and MCF-7	–	376^d	250	42	–	[98]
Core/shell: Fe3O4@mSiO2 with polymer as a gatekeeper	65	DOX	Hela	–	–	250	47	–	[87]
Zinc-doped iron oxide nanocrystals (ZnNCs)containing MSNs, which have beensurface-decorated with valves	∼250	DOX	MDA-MB-231	–	37.4^e	500	52 (in water)	–	[90]
MagneticNanoAssemble@Dye-SiO2@SiO2	60–80	–	HeLa cells	–	13.3^e	250	42–45	218	[53]
Maghemite @ mesoporous silica microspheres	300–3000	–	M1 cells^a	–	200^d	100	44	–	[95]
Silica coated La0.56(SrCa)0.22MnO3	300	–	HeLa	–	15^c	100	37.5	–	[65]
Silica coated La1-xSrxMnO3	50–100	–	rMSCs^b	–	6.4^e	481	45	∼50	[62]
Fe3O4/SiO2	∼15	–	HeLa cells	–	400^f	250	43	111	[77]

^a transformants of HeLa cells.

^b rat mesenchymal stem cells.

^c mT.

^d Oe.

^e kAm⁻¹.

^f applied current =400 A.

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