Figures & data
Figure 1. Schematic overview of targeting CSCs by hyperthermia. The tumour consists of many different cell types including CSCs. Conventional first-line radiotherapy and chemotherapy are able to destroy all tumour cells and especially CSCs that often reside in hypoxic areas. These cells are considered to drive tumour recurrence and metastasis formation. Combined with conventional first-line treatment, hyperthermia can target CSCs via multiple avenues, including stimulation of blood flow and re-oxygenation of hypoxic areas, causing blood vessel leakage, triggering the immune response and inhibiting DNA repair.
