Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer

Figures & data

Table 1. Patient characteristics.

Parameter	Values
Gender (male/female, n)	26/5
Age (years)	61 ± 12
Height (cm)	163.0 ± 7.1
Body weight (kg)	56.8 ± 11.5
BMI (kg/m^2)	21.1 ± 3.5
Original cancer diagnosis, n (%)
Lung	7 (22.6)
Colon	7 (22.6)
Stomach	6 (19.4)
Oesophagus	4 (12.9)
Pancreas	3 (9.7)
Thymus	1 (3.2)
Others	3 (9.7)
Lung metastasis, n (%)	12 (38.7)
Stage, n (%)
<Stage 3	5 (16.1)
≥Stage 3	26 (83.9)
Performance status score 0/1/2/3/4, n (%)	1(3.2)/25 (80.6)/5 (16.2)/0/0
Main treatment, n (%)
Chemotherapy	28 (90.3)
Being treated	24
Paclitaxel	6
Irinotecan	4
Paclitaxel + Carboplatin	3
TS-1	2
Others	9
Temporary Stopped	4
Radiotherapy	3 (9.7)
Positions during HT
Prone	23 (74.2)
Supine	8 (25.8)
Heated areas
Chest	13 (41.9)
Upper abdomen	18 (58.1)
Complications, n (%)
Hypertension	11 (35.5)
Diabetes	8 (25.8)
Laboratory data
TP (g/dL)	6.6 ± 0.4
Alb (g/dL)	3.6 ± 0.5
RBCs (×10^4/μL)	341 ± 55
Hb (g/dL)	11.3 ± 1.6

BMI: body mass index; TP: total protein; Alb: albumin; RBCs: red blood cells; Hb: haemoglobin.

Figure 1. Experimental protocol. HT: hyperthermia therapy; T_rec: rectal temperature; BP: blood pressure; PR: pulse rate; SpO₂: oxygen saturation of the peripheral artery; BW: body weight.

Figure 2. The serial changes in the rectal temperature during HT therapy. n = 31. The data are presented as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001 vs. 0 min.

Figure 3. The serial changes in the (A) PR and (B) blood pressure during HT therapy. n = 31. The data are presented as the mean ± SD, **p < 0.01, ***p < 0.001 vs. 0 min. (C) The individual changes of the systolic and diastolic blood pressure on standing after HT. n = 31. ΔSBP means the difference value of SBP between the end of HT on recumbent position and upright position after HT. ΔDBP means the difference value of DBP between the end of HT on recumbent position and upright position after HT.

Figure 4. The serial changes in the (A) RR and (B) SpO₂ during HT therapy. n = 31. The data are presented as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001 vs. 0 min.