Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma and predictors of survival

Figures & data

Figure 1. Study population and distribution of histological subtypes.

Table 1. Demographic and surgical characteristics of 76 peritoneal mesothelioma patients.

	Study population (n = 76)	LGPM (n = 39)	DMPM (n = 37)	p value
Gender (female)
Number (%)	34 (44.7%)	22 (56.4%)	12 (32.4%)	0.036^a
Age (years)
Median (range)	49 (21–73)	44 (21–69)	56 (32–73)	0.001^b
Complete cytoreduction
Number (%)	52 (68.4%)	34 (87.2%)	18 (48.6%)	0.001^a
LOS (days)
Median (range)	15 (5–62)	15 (7–32)	15 (5–62)	0.576^b
Surgical duration (minutes)
Median (range)	420 (30–720)	420 (30–630)	420 (120–720)	0.559^b
Blood loss (L)
Median (range)	1.0 (0.2–2.5)	0.5 (0.2–2.0)	1.0 (0–2.5)	0.079^b
PCI
Median (range)	15 (3–39)	9 (3–39)	18 (3–39)	0.001^b
Ki-67 proliferation index (%)
Median (range)	7 (0–50)	3.5 (0–50)	9.2 (0–49)	0.003^b

DMPM: diffuse malignant mesothelioma; LOS: length of stay; LGPM: low-grade peritoneal mesothelioma; PCI: Peritoneal Cancer Index.

^aPearson’s chi-square test.

^bMann–Whitney U test.

Figure 2. Kaplan–Meier curves for overall (A) and disease-free (B) survival for patients with low-grade peritoneal mesothelioma (LGPM) and diffuse malignant peritoneal mesothelioma (DMPM).

Table 2. Survival outcomes after complete cytoreduction by histological subtype.

	LGPM	DMPM	p value
Overall survival (months)
Mean (95% CI)	152.0	45.7 (28.2–63.2)	0.001^a
3 years (%)	100	62.5
5 years (%)	100	37.5
Disease-free survival (months)
Mean (95% CI)	74.7 (62.3–87.0)	28.5 (15.0–42.0)	0.001^a
3 years (%)	88.4	34.7
5 years (%)	83.3	34.7

DMPM: diffuse malignant peritoneal mesothelioma. LGPM: low-grade peritoneal mesothelioma.

^aLog-rank test.

Figure 3. Kaplan–Meier curve showing significant difference in overall survival after complete cytoreduction between DMPM patients with high or low Ki-67 proliferation index.