Assessment of nephrotoxicity associated with combined cisplatin and mitomycin C usage in laparoscopic hyperthermic intraperitoneal chemotherapy

Figures & data

Table 1. Summary of patient characteristics.

	N = 23
Age
Mean ± SD	54.3 ± 15.4
Median (min to max)	57 (21 to 75)
Body mass index
Mean ± SD	26.4 ± 4.5
Median (min to max)	24.8 (20.3 to 36.1)
Body surface area
Mean ± SD	1.9 ± 0.2
Median (min to max)	1.9 (1.4 to 2.2)
Gender
Female	8 (34.8)
Male	15 (65.2)
American Society of Anesthesiologists Physical Status
2	1 (3.23)
3	22 (95.6)

Table 2. Summary of clinical characteristics.

	N = 31 (%)
Crystalloid fluids, mL
Mean ± SD	1603.2 ± 889.1
Median (min to max)	1400 (200 to 5000)
Colloid fluids, mL
0: No fluids administered	27 (87.1)
450	1 (3.2)
500	2 (6.4)
1000	1 (3.2)
Total no. of hypotensive episodes
0	18 (58.1)
1	1 (3.2)
2	6 (19.4)
3	2 (6.4)
4	2 (6.4)
8	1 (3.2)
10	1 (3.2)
Estimated time hypotensive, minutes
Mean ± SD	1.4 ± 2.4
Median (min to max)	0 (0 to 10)

Figure 1. Trends in creatinine, glomerular filtration rate (GFR), and hemoglobin (HGB).

Table 3. Longitudinal summary of Creatinine, GFR and HGB.

	PreOP, N = 31	PostOp Day 0, N = 31	PostOp Day 1, N = 31	PostOp Day 2, N = 31	Change from Baseline to POD#2^a
Creatinine
Mean ± SD	0.86 ± 0.21	0.71 ± 0.15	0.73 ± 0.18	0.85 ± 0.19	0.13 ± 0.11
Median (min to max)	0.84 (0.52 to 1.28)	0.75 (0.47 to 1.03)	0.68 (0.44 to 1.09)	0.8 (0.56 to 1.25)	0.09 (0 to 0.43)
					p < 0.001
GFR
Mean ± SD	90.90 ± 23.95	111.39 ± 22.31	109.64 ± 25.39	93.03 ± 23.05	−18.36 ± 13.84
Median (min to max)	86 (55 to 155)	110 (73 to 166)	106 (68 to 166)	91 (58 to 166)	−17 (−42 to 11)
					p < 0.001
HGB
Mean ± SD	12.02 ± 1.48	10.81 ± 1.57	10.44 ± 1.40	10.43 ± 1.35	−0.38 ± 0.91
Median (min to max)	12.1 (9.1 to 15.4)	11 (7.7 to 13.9)	10.6 (7.8 to 13.3)	10.5 (7.3 to 13)	−0.2 (−2.2 to 1.1)
					p = 0.052

Notes: ^aThe change from baseline was computed by taking the difference between measurements at POD#2 and Baseline. p values pertain to a Wilcoxon signed-rank test.

Table 4. Assessments of calcium, phosphate and magnesium.

	Preoperative, N = 28	Postoperative, N = 31	p	Change from preoperative, N = 28
Calcium	n = 25			N = 25
Mean ± SD	9.22 ± 0.66^a	7.2 ± 1.32	<0.001	−1.82 ± 0.58^a
Median (min to max)	9.3 (7.7 to 10.3)^a	7.4 (0.7 to 8.5)		−1.9 (−2.8 to −0.6)^a
Phosphorous	n = 26			N = 26
Mean ± SD	4.03 ± 0.45^b	2.12 ± 0.97	<0.001	−2.08 ± 0.54^b
Median (min to max)	4 (3.1 to 4.9)^b	2 (1.0 to 6.6)		−2.2 (−3.2 to −1.2)^b
Magnesium	n = 28			N = 28
Mean ± SD	1.94 ± 0.17^a	1.98 ± 0.20	0.253	0.04 ± 0.25
Median (min to max)	1.9 (1.5 to 2.3)^a	1.9 (1.6 to 2.4)		0.0 (−0.6 to 0.9)

Notes: ^aThree observations missing; ^bTwo observations missing.