The effect of high-intensity focused ultrasound guided by magnetic resonance therapy on obstetrical outcomes in patients with uterine fibroids – experiences from the main Polish center and a review of current data

Figures & data

Table 1. Sonification effects and fibroid characteristics in patients who conceived after MR-HIFU treatment.

Patient number	NPVR%	Sonification time (min)	Maximal sonification power (W)	Maximal sonification temperature (^oC)	Fibroid volume at the time of qualification (cm^3)	Funaki type
1	90	89	220	81	333.4	I
2	90	293	240	84	190	II
3	50	80	160	105	191.2	II
4	50	54	120	73	10.8	I
5	90	73	170	73	13.6	II
6	90	90	150	69	19.3	II
7	95	75	140	72	28.7	I
8	90	93	180	72	28.6	I
9	60	167	180	72	50.5	I
10	50	104	220	84	32.5	II
11	50	92	170	87	36.5	I
12	90	101	200	72	63.6	II
13	60	193	130	81	181	II
14	60	95	150	69	80.5	II
15	75	176	230	79	109.9	II
16	100	117	220	79	53.9	II
17	60	53	220	70	95.5	II
18	100	113	190	72	79.8	II
19	55	117	170	84	49.2	II
20	80	124	200	70	81.8	II
Average	74	115	183	77	86.5

Table 2. General alleviation of symptoms and fibroid volume change after MR-HIFU therapy in described patients.

Patient number	Fibroid volume at the time of qualification (cm^3)	General alleviation of UF-related symptoms	Fibroid volume 3 months after the procedure (cm^3)	% of the initial volume	Fibroid volume 6 months after the procedure (cm^3)	% of the initial volume
1	333.4	Yes	LOD	LOD	LOD	LOD
2	190	Yes	99.2	52.2%	96.7	50.9%
3	191.2	Yes	25.4	13.3%	28	14.7%
4	10.8	No change	13.7	127.2%	16.8	155.4%
5	13.6	Yes	15	110.8%	6.6	48.9%
6	19.3	Yes	15.3	79.1%	13.7	71.0%
7	28.7	Yes	19.9	69.5%	LOD	LOD
8	28.6	LOD	LOD	LOD	LOD	LOD
9	50.5	Yes	LOD	LOD	24.3	48.0%
10	32.5	Yes	17.7	54.4%	18.4	56.7%
11	36.5	No change	34.9	95.6%	46.3	126.7%
12	63.6	Yes	LOD	LOD	36	56.6%
13	181	Yes	330	182.3%	227.5	125.7%
14	80.5	No change	97.1	120.6%	140.5	174.6%
15	109.9	Yes	109.9	100.0%	86.6	78.8%
16	53.9	Yes	13.8	25.5%	10.1	18.7%
17	95.5	Yes	82.6	86.5%	LOD	LOD
18	79.8	Yes	24.9	31.2%	27.6	34.6%
19	49.2	Yes	19.7	40.0%	12.3	25.1%
20	81.8	Yes	59.8	73.1%	48.5	59.3%
Average	86.5	N/A	61.2	78.8%	52.5	71.6%

LOD: lack of data; N/A: not applicable.

Table 3. Data concerning pregnancies and labor characteristics in patients who conceived after MR-HIFU treatment.

Patient number	No. of pregnancies before MR-HIFU	No. of miscarriages before MR-HIFU	No. of pregnancies after MR-HIFU	No. of miscarriages after MR-HIFU	Child born after MR-HIFU	CS/VD	Cause of CC	Week of pregnancy at the time of delivery	Birth weight (g)	Points in Apgar scale
1	1	0	1	0	Yes	CS	CS in past, threatening scar dehiscence	38	4360	10
2	1	1	1	0	Yes	CS	Elective	40	3360	10
3	0	0	2	1	Yes (GDM)	CS	Elective	LOD	3540	LOD
4	0	0	1	0	Yes	VD	N/A	39	3800	9
5	0	0	1	0	Yes	VD	N/A	38	3420	10
6	0	0	1	0	Yes	CS	Elective	38	3380	10
7	0	0	1	0	Yes	CS	Lack of labor progress	38	3890	10
8	1	0	1	0	Yes	VD	N/A	39	3920	10
9	0	0	1	0	Yes	VD	N/A	40	3300	9
10	0	0	1	0	Yes (GDM)	CS	LOD	38	3370	10
11	0	0	1	0	Yes	CS	LOD	40	3500	10
12	1	0	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A
13	0	0	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A
14	0	0	1	1	No	N/A	N/A	N/A	N/A	N/A
15	1	1	1	1	No	N/A	N/A	N/A	N/A	N/A
16	0	0	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A
17	1	1	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A
18	1	1	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A
19	0	0	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A
20	0	0	1	0	Pregnant	N/A	N/A	N/A	N/A	N/A

No: number; CS: cesarean section; VD: vaginal delivery; LOD: lack of data; N/A: not applicable.

Data availability statement

The data used to support the findings of this study are available from the corresponding author upon request.