PIPAC versus HIPEC: cisplatin spatial distribution and diffusion in a swine model

Figures & data

Table

Station	Biopsy sites
s1	Right hemi-diaphragm peritoneum
s2	Central diaphragmatic peritoneum
s3	Left hemi-diaphragm peritoneum
s4	Left flank peritoneum
s5	Left iliac fossa peritoneum
s6	Pelvic peritoneum
s7	Right iliac fossa peritoneum
s8	Right flank peritoneum
s9	Anterior abdominal wall peritoneum
s10	Full-wall jejunum biopsy

Figure 1. Boxplot showing topographic distribution of cisplatin tissular concentrations in the HIPEC and PIPAC groups. For each station, comparison has been performed between HIPEC and PIPAC groups using non-parametric tests (exact Mann–Whitney test). IQR: interquartile range.

Table 1. Tissular platinum concentrations.

(a) Tissular platinum tissular concentrations in the PIPAC group according to peritoneum stations as described in Box 1
	pP1	pP2	pP3	pP4	pP5	pP6	pP7	pP8	Median by station (IQR)
s1	2.92	20.20	1.62	10.41	4.62	12.97	13.64	3.74	7.52 (3.33–13.31)
s2	2.20	10.70	0	2.60	0.46	3.98	6.43	0	2.4 (0.23–5.21)
s3	3.80	6.03	0.46	3.38	4.80	11.97	10.77	0.38	4.3 (1.92–8.40)
s4	20.75	4.36	14.82	7.79	50.85	10.20	33.90	15.58	15.2 (9.00–27.33)
s5	4.11	2.86	1.61	7.15	8.44	17.88	4.21	2.67	4.16 (2.77–7.80)
s6	13.32	2.99	1.17	32.64	0.66	2.41	1.69	1.10	2.05 (1.14–8.16)
s7	13.81	17.78	1.56	13.64	3.23	1.66	4.61	4.75	4.68 (2.45–13.73)
s8	6.47	24.38	3.10	26.67	3.18	11.52	9.38	11.35	10.37 (4.83–17.95)
s9	8.12	23.51	1.33	12.73	3.02	15.00	9.24	3.99	8.68 (3.51–13.87)
s10	0.85	1.44	0	1.70	0.49	0	0.81	0.71	0.76 (0.25–1.15)
Median by pig	5.29	8.37	1.45	9.10	3.21	10.86	7.84	3.21	4.49
(b) Tissular platinum concentrations in the HIPEC group according to peritoneum stations as described in Box 1
	pH1	pH2	pH3	pH4	pH5	pH6	pH7	pH8	Median by station (IQR)
s1	12.90	36.68	33.08	18.67	18.47	22.30	38.03	5.08	20.49 (15.69–34.88)
s2	21.15	7.30	7.63	4.87	2.23	14.03	27.64	4.70	7.47 (4.79–17.59)
s3	19.49	51.14	9.62	11.10	2.74	55.76	21.19	17.96	18.73 (10.36–36.17)
s4	27.20	89.02	47.48	62.86	6.82	33.86	18.96	24.33	30.53 (21.65–55.17)
s5	15.31	25.98	9.69	18.13	3.52	10.68	8.29	16.26	13.00 (8.99–17.20)
s6	2.62	11.17	10.41	12.72	24.68	10.85	7.41	17.49	11.01 (8.91–15.11)
s7	18.53	26.46	30.00	32.38	45.85	6.68	56.30	29.84	29.92 (22.50–39.12)
s8	28.09	50.66	47.47	16.15	77.38	19.24	95.11	32.89	40.18 (23.67–64.02)
s9	9.32	44.91	46.22	10.48	5.89	31.72	31.64	9.72	21.06 (9.52–38.32)
s10	0.17	4.35	2.69	4.18	3.75	3.92	4.16	2.11	3.84 (2.40–4.17)
Median by pig	16.92	31.57	20.21	14.44	6.36	16.64	24.42	16.88	19.61

(a) Results are mean (standard deviation) of tissular concentrations expressed in mg/g.

pPx: pig from the PIPAC group number x; sX: station X; IQR: interquartile range.

(b) Results are mean (standard deviation) of tissular concentrations expressed in mg/g.

pHx: pig from the HIPEC group number x; sX: station X; IQR: interquartile range.

Figure 2. Comparison of plasmatic cisplatin concentration between HIPEC and PIPAC.

Table 2. Cisplatin plasmatic concentrations according to time of sampling.

	HIPEC^a	PIPAC	p Value
T + 0′	0.513 (0.174)	0.083 (0.016)	<.001
T + 30′	0.425 (0.122)	0.121 (0.021)	<.001
T + 60′	0.381 (0.111)	0.101 (0.022)	<.001

Values are mean (standard deviation) expressed in expressed in mg/L.

T + x′, timing of sampling (numbers expressed in min).

^a Mean was calculated with data from six pigs.