The impact of ultrasound-guided high-intensity focused ultrasound for uterine fibroids on ovarian reserve

Figures & data

Table 1. Baseline characteristics of the 84 enrolled patients.

Variables	Value
No. patients	84
Age (years)	38 (range:24–45)
Multiple fibroids	38
Solitary fibroid	46
Median uterine volume (cm^3)	198.56 (interquartilerange: 137.26–295.26)
Median fibroid volume (cm^3)	71.95 (interquartile range: 42.44–126.41)

Table 2. Treatment results of uterine fibroids treated by HIFU.

	Median (interquartile range)
Sonication time (s)	728.5 (497.8–1231.3)
sonication energy (J)	261,421.0 (178,241.3–468,311.8)
Nonperfused volume ratio	80.0% (70.0−90.0%)

Figure 1. AMH values of the patients younger than 35 years of age.

Table 3. AMH levels in different age groups assessed before and 6 months after HIFU.

Age	Median (interquartile range) treatment		p Value
	Pre-HIFU (ng/mL)	6-M after HIFU (ng/mL)
<35 years (N = 27)	3.04 (1.10–5.02)	3.24 (0.95–4.75)	0.117
36–40 years (N = 20)	1.73 (1.04–2.81)	1.44 (0.79–1.92)	0.020*
41–45 years (N = 17)	0.87 (0.37–2.01)	0.75 (0.40–1.63)	0.703

*indicates a significant difference.

Figure 2. AMH values of the patients between 36 and 40 years of age.

Figure 3. AMH values of the patients between 41 and 45 years of age.

Figure 4. A sagittal plane of contrast enhanced MRI obtained from a 43-year-old patient with multiple uterine fibroids before and 1 day after HIFU treatment. (A) pre-HIFU image showed multiple uterine fibroids with poor to medium blood supply; (B) post-HIFU image showed the multiple uterine fibroids were completely ablated without damaging to the normal structures of the uterus.