Safety and efficacy of intravesical chemotherapy and hyperthermia in the bladder: results of a porcine study

Figures & data

Figure 1. (a) Tear Drop Thermistors: (1) Yellow (left); (2) Blue (Strip Bottom); (3) Yellow/Black (Posterior); (4) Red (Base); (5) White (Right); (6) Transparent (Anterior); (7) Blue/Black (Strip Top); (8) Green (Dome). Strip: 1 cm apart on Kapton Flexible Strip. (b) Surface Mount Thermistor Strip.

Figure 2. Combat BRS Temperature profile.

Figure 3. Median mitomycin C concentration in various organs and bodily fluid.

Figure 4. Jitter plot evaluation mitomycin C concentration in various organs at necropsy sorted by body temperature and 43 °C using the Combat BRS bladder hyperthermia device. (Each dot represents a sample of different dwell times and dosages).

Table 1. Mitomycin C concentration in bladder wall based on dwell time, dose and hyperthermia.

Bladder wall mitomycin C concentration (ng/mL)
Dwell time (mins)	Dose (mg)	Body temperature			Hyperthermia 43 °C			p value
		N	Median	IQR	N	Median	IQR
60 mins	0 mg	–	–	–	3	0	0–5
60 mins	40 mg	4	329	260–662	4	471	260–1029	0.012
180 mins	40 mg	–	–	–	5	242	169–247
60 mins	80 mg	3	617	311–785	3	7135	3604–9107	0.004
30 mins	120 mg	3	3970	2401–13040	3	6822	5901–7048	0.004
120 mins	120 mg	3	353	273–8459	4	437	304–1034	0.002