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International Journal of Hyperthermia Volume 38, 2021 - Issue 1
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Articles

A multicenter randomized phase II trial of hyperthermia combined with TPF induction chemotherapy compared with TPF induction chemotherapy in locally advanced resectable oral squamous cell carcinoma

Guoxin Rena Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
,
Houyu Jua Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
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Yunteng Wua Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
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Hao Songa Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
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Xuhui Maa Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
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Minghua Gec Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, ChinaView further author information
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Weiliu Qiua Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
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Yazhu Chend Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai Med-X Engineering Center for Medical Equipment and Technology, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
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Yue Hea Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaView further author information
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Qianwei Zhuange Department of Oromaxillofacial Head and Neck Surgery, College of Medicine, Affiliated Xuzhou Hospital, Southeast University, Xuzhou, ChinaView further author information
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Jian Menge Department of Oromaxillofacial Head and Neck Surgery, College of Medicine, Affiliated Xuzhou Hospital, Southeast University, Xuzhou, ChinaCorrespondence[email protected]
View further author information
&
Wei Guoa Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China;b Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1946-8765View further author information
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Pages 939-947 | Received 24 Mar 2021, Accepted 27 May 2021, Published online: 16 Jun 2021

Figures & data

Figure 1. (A) Ultrasonic thermal therapy system; (B) Representative CT scan of OSCC patients pre- and post-hyperthermia therapy; (C) Representative section of hematoxylin and eosin staining post-hyperthermia therapy in OSCC patients.

Figure 1. (A) Ultrasonic thermal therapy system; (B) Representative CT scan of OSCC patients pre- and post-hyperthermia therapy; (C) Representative section of hematoxylin and eosin staining post-hyperthermia therapy in OSCC patients.

Figure 2. CONSORT diagram.

Figure 2. CONSORT diagram.

Table 1. Baseline patient demographic and clinical characteristics.

Table 2. Clinical response of hyperthermia.

Figure 3. (A) Overall and (B) disease-free survival in the control and experimental arms. TPF: docetaxel, cisplatin, and fluorouracil.

Figure 3. (A) Overall and (B) disease-free survival in the control and experimental arms. TPF: docetaxel, cisplatin, and fluorouracil.

Table 3. Toxicity.

Figure 4. (A) disease-free and (B) Overall survival of response and non-response patients in total population; (C) disease-free and (D) Overall survival of response and non-response patients in experimental arm; (E) disease-free and (F) Overall survival of response and non-response patients in control arm.

Figure 4. (A) disease-free and (B) Overall survival of response and non-response patients in total population; (C) disease-free and (D) Overall survival of response and non-response patients in experimental arm; (E) disease-free and (F) Overall survival of response and non-response patients in control arm.

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