The efficacy and safety of secondary focused ultrasound therapy for recurrence of non-neoplastic epithelial disorders of the vulva

Figures & data

Table 1. The demographic characteristics of patients with recurrence of non-neoplastic epithelial disorders of the vulva.

Demographic characteristics	Values
Age, years	47.4 ± 11.4
Time between relapse and initial treatment, years	1.5 (0.5, 10.0)
Course of diseases recurrence, years	1.0 (0.1, 8.0)
Menopause
Pre-menopause	52 (53.1)
Post- menopause	46 (46.9)
Symptoms
Mild	4 (4.1)
Moderate	31 (31.6)
Severe	63 (64.3)
Lesion size/vulva size
<30%	22 (22.5)
30–50%	46 (46.9)
>50%	30 (30.6)
Pathological type
lichen sclerosus	31 (31.6)
lichen simplex chronicus	67 (68.4)

Values are given as n (%) unless otherwise stated.

Table 2. The results pertaining to the focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva recurrence.

Variables	Values
Sessions of focused ultrasound therapy	1
Sonication time, min	22.4 ± 8.1
Power
Level 2	40 (40.8)
Level 3	58 (59.2)
Treatment energy, J	4179.0 (1527, 10388.0）
Adverse effects
Blisters	16 (16.3)
Ulcer	6 (6.1)
Efficacy
Curative	46 (46.9)
Effective	44 (44.9)
Ineffective	8 (8.2)

Values are given as n (%) unless otherwise stated.

Table 3. Comparison of the therapeutic effect on different influential factors.

Variable	Cure, %	Effective, %	Ineffective, %	p Value
Age, years				0.235
<47	26 (55.3)	17 (36.2)	4 (8.5)
≥47	20 (39.2)	27 (52.9)	4 (7.8)
Menopause				0.812
Pre-menopause	26 (50.0)	22 (42.3)	4 (7.7)
Post-menopause	20 (43.5)	22 (47.8)	4 (8.7)
Course of diseases recurrence, years				0.332
<1	16 (42.1)	17 (44.7)	5 (13.2)
≥1	30 (50.0)	27 (45.0)	3 (5.0)
Time between relapse and initial treatment, years				<0.001
<1.5	8 (20.0)	25 (62.5)	7 (17.5)
≥1.5	38 (65.5)	19 (32.8)	1 (1.7)
Symptoms				0.404
Mild	3 (75.0)	1 (25.0)	0
Moderate	16 (51.6)	12 (38.7)	3 (9.7)
Severe	27 (42.9)	31 (49.2)	5 (7.9)
Lesion size/vulva size				0.095
<30%	14 (63.6)	7 (31.8)	1 (4.5)
30–50%	20 (43.5)	21 (45.7)	5 (10.9)
>50%	12 (40.0)	16 (53.3)	2 (6.7)
Pathological type				0.675
lichen sclerosus	12 (38.7)	17 (54.8)	2 (6.5)
lichen simplex chronicus	34 (50.7)	27 (40.3)	6 (9.0)
Power				0.420
Level 2	19 (47.5)	15 (37.5)	6 (15.0)
Level 3	27 (46.6)	29 (50.0)	2 (3.4)

Values are given as n (%) unless otherwise stated.