Attributes underlying patient choice of treatment modality for low-grade squamous intraepithelial lesion complicated by high-risk human papillomavirus infection

Figures & data

Table 1. One-way ANOVA of attributes underlying patient choice of treatment modality for LSIL complicated with HR-HPV infection.

Influencing factors	Interferon group (n = 57)	PDT group (n = 36)	FUS group (n = 47)	Follow-up observation group (n = 57)	p
Age (years)	39.6 ± 10.7 b	36.3 ± 11.9 a	27.7 ± 5.8 abc	41.9 ± 11.1 c	0.000
Occupation (yes/none)	36/21	28/8	37/10	41/16	0.278
Education level (1/2/3^1)	23/13/21	7/11/8	3/15/29	22/10/25	0.001
Maternity history (1/2/3^2)	8/36/13	10/16/10	31/14/2	6/35/16	0.000
Reason for encounter (physical examination/screening)	49/8	33/3	47/0	46/11	0.026
Route of consultation (voluntary/suggested)	52/5	36/1	47/0	54/3	0.289
Personal income (1/2^3)	21/36	17/19	17/30	27/30	0.515
Household income (1/2/3/4/5^4)	1/10/27/14/5	1/17/8/7/3	0/8/22/14/3	5/18/19/7/8	0.010

a: a significant difference in age between FUS and PDT.

b: a significant difference in age between FUS and interferon therapy.

c: Significant difference in age between FUS and follow-up observation treatment.

¹Education level: 1 = middle school or below; 2 = high school; 3 = bachelor’s degree and above.

²Maternity history: 1: no births; 2: 1 birth; 3: two or more births.

³Annual personal income: 1: <60,000 RMB; 2: ≥60,000 RMB.

⁴Annual household income: 1: ≤50,000 RMB; 2: 60–100,000 RMB; 3: 110–150,000 RMB; 4: 160–200,000 RMB; 5: >200,000 RMB.

Table 2. Influencing factors assignment.

Variables	Influencing factors	Assignment
Y	Treatment modality for LSIL complicated with HR-HPV infection	Interferon therapy = 1; PDT = 2; Follow-up observation treatment = 3; FUS treatment = 4
X 1	Age	≤35 years = 1; > 35 years = 2
X 2	Education level	≤ Middle school =1; High school = 2; ≥ Bachelor’s degree = 3
X 3	Maternity history	No births = 0, 1; birth = 1, 2; more births = 2
X 4	Reason for encounter	Physical examination = 1; screening = 2
X 5	Annual household income	≤50,000 RMB = 1; 60–100,000 RMB = 2; 110–150,000 RMB = 3; 160–200,000 RMB = 4; >200,000 RMB = 5

Table 3. Multivariate logistic regression analysis of factors affecting the choices of treatment modality for LSIL complicated with HR-HPV infection.

	Interferon therapy			PDT			Follow-up observation treatment
	B	Wald df	Sig	B	Wald df	Sig	B	Wald df	Sig
Intercept	12.634	37.672	0.000	13.589	39.305	0.000	13.793	49.027	0.000
Age 1 (≤35 years old)	0.142	10.648	0.002	0.114	6.441	0.058	0.151	11.713	0.000
Age 1 (>35 years old)	.	.	.	.	.	.	.	.	.
Education level 1 (middle school or below)	0.380	0.181	0.671	1.104	1.210	0.271	1.012	1.140	0.286
Education level 2 (high school)	0.644	1.176	0.278	0.632	1.093	0.296	1.343	4.459	0.035
Education level 3 (Bachelor’s degree and above)	.	.	.	.	.	.	.	.	.
Maternity history 0 (no birth)	1.624	2.583	0.108	2.258	4.866	0.027	2.460	5.502	0.019
Maternity history 1 (1 birth)	0.412	0.207	0.649	1.198	1.658	0.198	0.712	0.607	0.436
Maternity history 2 (2 or more births)	.	.	.	.	.	.	.	.	.
Reason for encounter (Physical examination/screening)	16.937	692.229	0.000	16.392	367.980	0.000	17.386	.	.
Annual household income 1 (≤50,000 RMB)	17.789	0.000	0.996	19.140	0.000	0.996	19.305	0.000	0.996
Annual household income 2 (60–100,000 RMB)	0.583	0.286	0.593	2.033	3.516	0.061	1.184	1.317	0.251
Annual household income 3 (110–150,000 RMB)	0.908	1.005	0.316	0.198	0.041	0.840	0.377	0.189	0.664
Annual household income 4 (160–200,000 RMB)	0.626	0.444	0.505	0.502	0.258	0.611	0.428	0.211	0.646
Annual household income 5 (>200,000 RMB)	.	.	.	.	.	.	.	.	.

Figure 1. Receiver operating characteristic curve for age.

Table 4. Efficacy analysis at six months after treatment in LSIL patients with HR-HPV infection.

Treatment modality	n	Effective	HR-HPV conversion negative	p-Value
Interferon therapy	57	21 (36.84)	20 (35.09)	0.000
Follow-up observation treatment	57	11 (19.30)	8 (14.04)	0.000
PDT	36	28 (77.78)	26 (72.22)	0.557
FUS	47	36 (76.60)	35 (74.47)	.

Note. Values are given as n (%) unless otherwise stated.

Table 5. Current status of treatment of patients with LSIL infection lasting two years or more (n = 95).

Factors	Treatment (n = 78)	Follow-up (n = 17)	p-Value
Age (years)	36.4 ± 1.2	36.5 ± 2.1	0.534
Occupation (yes/none)	62/16	13/4	0.533
Education level (1/2/3^a)	19/21/38	3/4/10	0.204
Maternity history (1/2/3^b)	27/35/16	3/10/4	0.632
Reason for encounter (physical examination/screening)	73/5	14/3	0.063
Route of consultation (voluntary/suggested)	75/3	17/0	0.509
Personal income (1/2^c)	20/58	8/9	0.037
Household income (1/2/3/4/5^d)	2/14/32/22/8	0/5/5/3/4	0.694

Note. The 2019 American Society for Colposcopy and Cervical Pathology (ASCCP) Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors (hereinafter referred to as the 2019 ASCCP guidelines): Management of LSIL persisting for two years or more: (a) follow-up observation (recommended); (b) treatment (optional).

^aEducation level: 1: middle school or below; 2: high school; and 3: bachelor’s degree and above.

^bMaternity history: 1: no births; 2: 1 birth; and 3: 2 or more births.

^cAnnual personal income: 1: <60,000 RMB; and 2: ≥60,000 RMB.

^dAnnual household income: 1: ≤50,000 RMB; 2: 60–100,000 RMB; 3: 110–150,000 RMB; 4: 160–200,000 RMB; and 5: >200,000 RMB.

Data availability statement

The data supporting the findings of this study are available from the corresponding author upon reasonable request.