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Aphasiology Volume 36, 2022 - Issue 4: Improving coordination of international aphasia research
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Special Issue: Improving coordination of international aphasia research

Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Louise R Williamsa Nursing Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UKORCID Iconhttps://orcid.org/0000-0003-2430-1142View further author information
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Myzoon Alia Nursing Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UKORCID Iconhttps://orcid.org/0000-0001-5899-2485View further author information
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Kathryn VandenBerga Nursing Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UKORCID Iconhttps://orcid.org/0000-0001-5035-9650View further author information
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Linda J Williamsb Usher Institute, University of Edinburgh, Edinburgh, UKORCID Iconhttps://orcid.org/0000-0002-6317-1718View further author information
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Masahiro Aboc Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0001-6701-4974View further author information
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Frank Beckerd Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, and Sunnaas Rehabilitation Hospital, Nesoddtangen, NorwayORCID Iconhttps://orcid.org/0000-0002-0857-0628View further author information
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Audrey Bowene Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, UKORCID Iconhttps://orcid.org/0000-0003-4075-1215View further author information
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Caitlin Brandenburgf School of Health and Rehabilitation Sciences, the University of Queensland, Brisbane, AustraliaORCID Iconhttps://orcid.org/0000-0002-6992-7790View further author information
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Caterina Breitensteing Department of Neurology with Institute of Translational Neurology, University of Muenster, Muenster, GermanyORCID Iconhttps://orcid.org/0000-0002-6408-873XView further author information
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Stefanie Bruehlh St Mauritius Rehabilitation Centre, Meerbusch, Germany; Clinical and Cognitive Neurosciences, Department of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, UKORCID Iconhttps://orcid.org/0000-0003-4826-1990View further author information
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David A Coplandf School of Health and Rehabilitation Sciences, the University of Queensland, Brisbane, AustraliaORCID Iconhttps://orcid.org/0000-0002-2257-4270View further author information
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Tamara B Cranfilli Department of Communication Sciences and Disorders, Eastern Kentucky University, Richmond, Kentucky, USAORCID Iconhttps://orcid.org/0000-0001-7608-6443View further author information
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Marie Di Pietro-Bachmannj Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, SwitzerlandORCID Iconhttps://orcid.org/0000-0001-8027-2337View further author information
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Pamela Enderbyk School of Health and Related Research, University of Sheffield, Sheffield, UKORCID Iconhttps://orcid.org/0000-0002-4371-9053View further author information
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Joanne Fillinghaml Nursing Directorate, NHS Improvement, London, UKORCID Iconhttps://orcid.org/0000-0002-0363-8021View further author information
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Federica Lucia Gallim Azienda Sanitaria Unica Regionale - ASUR, Marche Polytechnic University, Ancona, ItalyORCID Iconhttps://orcid.org/0000-0001-9244-9179View further author information
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Marialuisa Gandolfin Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, ItalyORCID Iconhttps://orcid.org/0000-0002-0877-4807View further author information
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Bertrand Glizeo EA 4136 Handicap Activity Cognition Health, University of Bordeaux, France;p Department of Physical Medicine and Rehabilitation, CHU De Bordeaux, FranceORCID Iconhttps://orcid.org/0000-0001-9618-2088View further author information
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Erin Godeckeq School of Medical and Health Sciences, Speech Pathology, Edith Cowan University and Sir Charles Gairdner Hospital, Perth, AustraliaORCID Iconhttps://orcid.org/0000-0002-7210-1295View further author information
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Neil Hawkinsr Institute of Health & Wellbeing, University of Glasgow, Glasgow, UKORCID Iconhttps://orcid.org/0000-0003-3199-221XView further author information
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Katerina Hilaris Centre for Language and Communication Science Research, City, University of London, London, UKORCID Iconhttps://orcid.org/0000-0003-2091-4849View further author information
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Jacqueline Hinckleyt Nova Southeastern University, Fort Lauderdale, Florida, USAORCID Iconhttps://orcid.org/0000-0002-4052-1420View further author information
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Simon Hortonu School of Health Sciences, University of East Anglia, Norwich, UKORCID Iconhttps://orcid.org/0000-0002-2133-1410View further author information
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David Howardv School of Education Communication and Language Sciences, Newcastle University, Newcastle-Upon-Tyne, UKORCID Iconhttps://orcid.org/0000-0001-9141-5751View further author information
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Petra Jaecksw Faculty of Linguistics and Literary Studies, Bielefeld University, Bielefeld, GermanyORCID Iconhttps://orcid.org/0000-0002-5878-1327View further author information
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Elizabeth Jefferiesx Department of Psychology, University of York, York, UKORCID Iconhttps://orcid.org/0000-0002-3826-4330View further author information
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Luis MT Jesusy School of Health Sciences (ESSUA) and Institute of Electronics and Informatics Engineering of Aveiro (IEETA), University of Aveiro, Aveiro, PortugalORCID Iconhttps://orcid.org/0000-0002-8534-3218View further author information
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Maria Kambanarosz Department of Rehabilitation Sciences, Cyprus University of Technology, Limassol, CyprusORCID Iconhttps://orcid.org/0000-0002-5857-9460View further author information
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Eun Kyoung Kangaa Department of Rehabilitation Medicine, Kangwon National University Hospital, Gangwon-do, Republic of KoreaORCID Iconhttps://orcid.org/0000-0001-5315-1361View further author information
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Eman M Khedrbb Department of Neurology, Assiut University Hospital, Assiut, EgyptORCID Iconhttps://orcid.org/0000-0001-5679-9833View further author information
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Anthony Pak-Hin Kongcc School of Communication Sciences and Disorders, University of Central Florida, Orlando, USAORCID Iconhttps://orcid.org/0000-0002-6211-0358View further author information
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Tarja Kukkonendd ENT/Department of Phoniatry, Tampere University Hospital, Tampere, FinlandORCID Iconhttps://orcid.org/0000-0002-8189-0337View further author information
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Marina Laganaroee Faculty of Psychology and Educational Science, University of Geneva, Geneva, SwitzerlandORCID Iconhttps://orcid.org/0000-0002-4054-0939View further author information
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Matthew A Lambon Ralphff MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UKORCID Iconhttps://orcid.org/0000-0001-5907-2488View further author information
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Ann Charlotte Laskagg Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, SwedenORCID Iconhttps://orcid.org/0000-0002-7330-940XView further author information
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Béatrice Leemannhh Neurorééducation, Département Des Neurosciences Cliniques, Hôpitaux Universitaires De Genève, Geneva, SwitzerlandORCID Iconhttps://orcid.org/0000-0003-2226-6777View further author information
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Alexander P Leffii Department of Brain Repair and Rehabilitation, Institute of Neurology, UCL, London, UKORCID Iconhttps://orcid.org/0000-0002-0831-3541View further author information
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Roxele Ribeiro Limajj Department of Speech Language Pathology, Educational Association Bom Jesus – IELUSC, Santa Catarina, BrazilORCID Iconhttps://orcid.org/0000-0002-9914-4789View further author information
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Antje Lorenzkk Department of Psychology, Humboldt-Universität zu Berlin, Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-0200-1977View further author information
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Brian MacWhinneyll Department of Psychology, Carnegie Mellon University, Pittsburgh, USAORCID Iconhttps://orcid.org/0000-0002-4988-1342View further author information
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Rebecca Shisler Marshallmm Department of Communication Sciences and Special Education, University of Georgia, Georgia, USAORCID Iconhttps://orcid.org/0000-0001-9313-5454View further author information
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Flavia Mattiolinn Neuropsychology Unit, ASST Spedali Civili of Brescia, Brescia, ItalyORCID Iconhttps://orcid.org/0000-0002-4912-5520View further author information
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İlknur Mavişoo Department of Speech and Language Therapy, Anadolu University, Eskişehir, TurkeyORCID Iconhttps://orcid.org/0000-0003-3924-1138View further author information
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Marcus Meinzerpp Department of Neurology, University Medicine Greifswald, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0003-1370-3947View further author information
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Reza Nilipourqq Department of Speech Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, IranORCID Iconhttps://orcid.org/0000-0003-4180-7989View further author information
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Enrique Noérr NEURORHB-Hospitales Vithas, Valencia, SpainORCID Iconhttps://orcid.org/0000-0002-2547-8727View further author information
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Nam-Jong Paikss Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaORCID Iconhttps://orcid.org/0000-0002-5193-8678View further author information
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Rebecca Palmerk School of Health and Related Research, University of Sheffield, Sheffield, UKORCID Iconhttps://orcid.org/0000-0002-2335-7104View further author information
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Ilias Papathanasioutt Department of Speech and Language Therapy, University of Patras, Patras, GreeceORCID Iconhttps://orcid.org/0000-0003-0999-696XView further author information
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Brigida F Patriciouu Department of Speech Therapy, School of Health, Polytechnic Institute of Porto, Porto, PortugalORCID Iconhttps://orcid.org/0000-0002-2619-470XView further author information
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Isabel Pavão Martinsvv Laboratório De Estudos De Linguagem, Faculdade De Medicina De Lisboa, Universidade De Lisboa, Lisbon, PortugalORCID Iconhttps://orcid.org/0000-0002-9611-7400View further author information
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Cathy Priceww Wellcome Centre for Human Neuroimaging, UCL, London, UKORCID Iconhttps://orcid.org/0000-0003-0111-9364View further author information
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Tatjana Prizl Jakovacxx Department of Speech and Language Pathology, Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb, CroatiaORCID Iconhttps://orcid.org/0000-0002-5018-9556View further author information
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Elizabeth Rochonyy Department of Speech-Language Pathology and Rehabilitation Sciences Institute, University of Toronto, and Toronto Rehabilitation Institute, Toronto, CanadaORCID Iconhttps://orcid.org/0000-0001-5521-0513View further author information
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Miranda L Rosezz Centre of Research Excellence in Aphasia Recovery and Rehabilitation, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, AustraliaORCID Iconhttps://orcid.org/0000-0002-8892-0965View further author information
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Charlotte Rossoaaa Institut Du Cerveau Et Del La Moelle Épinière, Sorbonne University, and APHP, Urgences Cérébro-Vasculaires, Hôpital De La Pitié Salpêtrière, Paris, FranceORCID Iconhttps://orcid.org/0000-0001-7236-1508View further author information
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Ilona Rubi-Fessenbbb RehaNova Rehabilitation Hospital and Department of Special Education and Rehabilitation, University of Cologne, Cologne, GermanyORCID Iconhttps://orcid.org/0000-0002-9775-3812View further author information
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Marina B Ruiterccc Sint Maartenskliniek, Rehabilitation Centre and Centre for Language Studies, Radboud University, Nijmegen, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-6147-5235View further author information
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Claerwen Snellddd Warrington and Halton Teaching Hospitals NHS Foundation Trust, Warrington, UKORCID Iconhttps://orcid.org/0000-0001-8606-7801View further author information
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Benjamin Stahleee Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, GermanyORCID Iconhttps://orcid.org/0000-0003-3957-1495View further author information
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Jerzy P Szaflarskifff UAB Epilepsy Centre, Department of Neurology, University of Alabama at Birmingham, Alabama, USAORCID Iconhttps://orcid.org/0000-0002-5936-6627View further author information
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Shirley A Thomasggg Division of Rehabilitation & Ageing; School of Medicine, University of Nottingham, Nottingham, UKORCID Iconhttps://orcid.org/0000-0003-0704-9387View further author information
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Mieke Van De Sandt-Koendermanhhh Department of Rehabilitation, Rijndam rehabilitation centre, Rotterdam, the Netherlands AND Eramus MC University Medical Centre, Rotterdam, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-8104-6937View further author information
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Ineke Van Der Meulenhhh Department of Rehabilitation, Rijndam rehabilitation centre, Rotterdam, the Netherlands AND Eramus MC University Medical Centre, Rotterdam, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-6156-3873View further author information
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Evy Visch-Brinkiii Department of Neurology and Neurosurgery, Erasmus University Medical Center, Rotterdam, NetherlandsORCID Iconhttps://orcid.org/0000-0001-7833-0112View further author information
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Linda Worrallf School of Health and Rehabilitation Sciences, the University of Queensland, Brisbane, AustraliaORCID Iconhttps://orcid.org/0000-0002-3283-7038View further author information
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Heather Harris Wrightjjj College of Allied Health Sciences, East Carolina University, Greenville, North Carolina, USAORCID Iconhttps://orcid.org/0000-0001-6922-6364View further author information
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Marian C Bradya Nursing Midwifery and Allied Health Professions Research Unit, Glasgow Caledonian University, Glasgow, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4589-7021View further author information
ORCID Icon & The RELEASE Collaborators show all
Pages 513-533 | Received 17 Aug 2020, Accepted 28 Jan 2021, Published online: 08 Oct 2021

Figures & data

Figure 1. PRISMA flow diagram: Eligible database identification and contribution.

Figure 1. PRISMA flow diagram: Eligible database identification and contribution.

Table 1. RELEASE database participant descriptors

Table 2. Data availability for language outcomes

Table 3. Overall language ability assessment tools (at baseline) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report, or unavailable

Table 4 a.Naming assessments (at baseline) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table b.Other spoken language assessments (at baseline) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table 5. Auditory comprehension assessments (at baseline) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table 6 a.Reading comprehension and writing assessments (at baseline) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table 6 b.Reading comprehension and writing assessments (at baseline) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table 7 a.Functional Communication (observer-rated) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table 7 b.Functional Communication (self-rated) included in RELEASE – Datasets and IPD where measure is reported, available, missing from report or unavailable

Table 8. Speech and language therapy (SLT) Interventions in the RELEASE dataset

Table 9. Significant and non-significant results reported, by participant number

Figure 2. Randomised controlled trials included in the RELEASE database and risk of bias.

Figure 2. Randomised controlled trials included in the RELEASE database and risk of bias.

Data availability statement & Data deposition

Contributing trialists who have granted permission for extended use of their datasets beyond RELEASE have deposited their data in the Collaboration of Aphasia Trialists’ (CATs) Aphasia Resource (available at https://www.aphasiatrials.org/aphasia-dataset/).

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