A single-centre study of frame-based stereotactic brain biopsies

Figures & data

Table 1. Specification of the study population.

Specifications
Age (years ± SD)	50 ± 15.7
Average number of samples taken per biopsy procedure	2
Number of biopsy procedures	125 (in 123 patients)
Male gender	76 (61.8%)

Table 2. Histopathological diagnoses acquired from the biopsies.

Histopathological diagnosis	n (%)
Neoplasms
Astrocytoma grade 3	30 (24.0)
B-cell lymphoma	22 (17.6)
Astrocytoma grade 4	21 (16.8)
Astrocytoma grade 2	20 (16.0)
Primitive neuroectodermal tumour	4 (3.2)
Anaplastic oligodendroglioma grade 3	3 (2.4)
Dysgerminoma	2 (1.6)
Ganglioglioma grade 1	2 (1.6)
Chronic lymphocytic leukemia	1 (0.8)
Diffuse intrinsic pontine glioma	1 (0.8)
Glioma grade 1	1 (0.8)
Metastasis	1 (0.8)
Oligoastrocytoma	1 (0.8)
Non-neoplasms
Inflammation	3 (2.4)
Reactive gliosis	2 (1.6)
Infection	1 (0.8)
Progressive multifocal leukoencephalopathy	1 (0.8)
Reactive changes, steroid treated lymphoma	1 (0.8)
Scar tissue	1 (0.8)
Vasculitis	1 (0.8)
Inconclusive	6 (4.8)
Total	125

Table 3. Outcome of biopsy procedures.

Type of complication	n (%)
No complication	112 (89.6)
Transient neurologic deficit	7 (5.6)
Other complications^a	3 (2.4)
Permanent neurologic deficit	2 (1.6)
Death (intracranial haemorrhage)	1 (0.8)
Total	125

^aAspiration pneumonia, damage to teeth from the intubation procedure, pulmonary embolism.

Table 4. Radiologists’ diagnosis compared to histopathological diagnosis.

Group	No. of matching cases (%)
First hand diagnosis	65 of 119 (54.6)
Astrocytoma grade 4	8 of 15 (53.3)
Lymphoma	7 of 8 (87.5)

Table 5. Mismatch factor between radiologists’ and the pathologists’ diagnosis.

Mismatch factor	No. of cases (%)
Different malignant cell type	16 (44.4)
Different type of lesion	8 (22.2)
Unspecified lesion	6 (16.7)
≥2 lower grades of tumour stage^a	3 (8.3)
≥2 higher grades of tumour stage^a	3 (8.3)
Total	36

^aWith matching cell-type.

Table 6. Number of cases with grade mismatch between radiologists’ and pathologists’ diagnosis.

Years	No. of procedures	No. of cases with grade mismatch (%)
2000–2005	59	16 (27.1)
2006–2011	27	5 (18.5)
2012–2017	39	3 (7.7)