Pre-hospital mild therapeutic hypothermia for patients with severe traumatic brain injury

Figures & data

Table 1. Main clinical and demographic characteristics between the two groups

Variable	Pre-hospital MTH group (n = 43)	Late MTH groups (n = 43)	P-values
No. male patients (%)	23 (53.4)	21 (48.8)	0.666
Mean age (years)	42.3 ± 1.8	40.6 ± 7.6	0.896
GCS score
3–5 (%)	10 (23.3)	12 (27.9)	0.621
6–8 (%)	33(76.7)	31 (72.1)
Mechanism of injury
Motor vehicle (%)	27(62.8)	29(67.4)	0.821
Fall (%)	12(27.9)	11(25.6)	1
Other (%)	4(9.3)	3(7.0)	0.907
Main CT scan classification
Extradural hematoma (%)	8(18.6)	9(20.9)	0.787
Subdural hematoma(%)	13 (14)	16(37.2)	0.648
Contusion (%)	7(16.3)	6 (12)	1
Brain swelling(%)	9(20.9)	7(16.3)	0.782
Others(%)	6 (12)	5(11.6)	1
Surgery (%)	38(88.4)	41(95.3)	0.237

CT, computed tomography;MTH:mild therapeutic hypothermia.

Table 2. Comparison of intracranial pressure dynamics between the two groups (mean ± SD)

Group	n	Intracranial pressure (mmHg)
		24 h after injury	48 h after injury	72 h after injury
Pre-hospital therapeutic hypothermia	43	17.38 ± 4.88*	18.40 ± 4.50*	16.40 ± 4.13*
Late therapeutic hypothermia	43	20.63 ± 3.00	21.80 ± 6.00	18.81 ± 4.50

Note: Compared with the late therapeutic hypothermia group, *P < 0.05.

Table 3. Comparison of prognosis between the two groups (number of cases)

Group	n	GOS score
		5	4	3	2	1
Pre-hospital therapeutic hypothermia	43	23 (53.5) *	5 (11.6)	4 (9.3)	0	11 (25.6)*
Late therapeutic hypothermia	43	12 (27.9)	4 (9.3)	5 (11.6)	0	22 (51.2)

Note: Compared with the late therapeutic hypothermia group, * P < 0.05.

Sarnaik A, Ferguson NM, O’Meara A, Agrawal S, Deep A, Buttram S, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, et al.Age and Mortality in Pediatric Severe Traumatic Brain Injury: results from an International Study. Neurocrit Care. 2018;28(3):302–13.doi:10.1007/s12028-017-0480-x.

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Karakitsos D, Karabinis A.Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008;359(11):1179–80.

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