47
Views
0
CrossRef citations to date
0
Altmetric
ARTICLES

Constitutive Pro-Apoptotic Molecules are Differentially Expressed in the Fetal and Adult Mouse Eye

&
Pages 328-332 | Received 15 Jul 2008, Accepted 11 Jan 2009, Published online: 02 Jul 2009
 

Abstract

Purpose: To compare gene expression of pro-apoptotic molecules in the fetal and adult mouse eye. Materials and Methods: Eyes were collected from groups of BALB/c mice, at embryonic ages E16 and E18 (fetal) or 6–8 weeks of age (adult). RNA extracted from pooled eyes was analyzed by real-time PCR for transcript levels of pro-apoptotic molecules involved in the intrinsic or extrinsic pathway of apoptosis. Results: Transcripts of intrinsic pathway molecules, Bad, Bak, and Bax, were relatively more highly expressed in the fetal mouse eyes, whereas extrinsic pathway molecules, Fas, FasL, and TRAIL had greater expression in the adult eyes. Conclusions: Different mechanisms of apoptosis are prominent at the fetal and mature stages of the mouse eye.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 555.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.