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Original Articles

Evaluation of Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution, 0.025% for Treatment of Ocular Redness

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Pages 43-51 | Received 31 Mar 2017, Accepted 25 Sep 2017, Published online: 09 Nov 2017

Figures & data

Table 1. Baseline subject demographics.

Figure 1. Investigator-evaluated ocular redness scores (0–4 scale) before and after instillation of brimonidine tartrate ophthalmic solution, 0.025% or its vehicle at Day 0 (Visit 1). Data are the mean (SD) for the ITT population with last observation carried forward.

Figure 1. Investigator-evaluated ocular redness scores (0–4 scale) before and after instillation of brimonidine tartrate ophthalmic solution, 0.025% or its vehicle at Day 0 (Visit 1). Data are the mean (SD) for the ITT population with last observation carried forward.

Figure 2. Percentage of subjects with total clearance of ocular redness at Day 0 (Visit 1) following instillation of brimonidine tartrate ophthalmic solution, 0.025% or its vehicle.

Figure 2. Percentage of subjects with total clearance of ocular redness at Day 0 (Visit 1) following instillation of brimonidine tartrate ophthalmic solution, 0.025% or its vehicle.

Table 2. Ocular redness (Mean [SD]) – subject diaries – ITT population with last observation carried forward.

Figure 3. Average daily post-instillation ocular redness scores (0–4 scale) based on subject diary data during treatment (Days 0 to 28) and for seven days following treatment discontinuation (Days 29 to 35). Data are the mean (SEM) for the ITT population with observed data only.

Figure 3. Average daily post-instillation ocular redness scores (0–4 scale) based on subject diary data during treatment (Days 0 to 28) and for seven days following treatment discontinuation (Days 29 to 35). Data are the mean (SEM) for the ITT population with observed data only.

Table 3. Ocular whitening – subject diaries – ITT population with observed data only.

Table 4. Rebound redness – safety population.

Table 5. Ocular adverse events – safety population.