Figures & data
Table 1. List of the inflammatory genes followed in this study.
Figure 1. Corneal fluorescein staining (CFS) scores over time upon treatment with the different anti-inflammatory eye drop medicinal products. Statistical significance was set at a p < 0.05. ****, p < 0.0001.
Figure 2. Corneal fluorescein staining (CFS) reduction at day 10 (vs. day 3, DED baseline) with the different anti-inflammatory eye drop treatments. Statistical significance was set at a p < 0.05. **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
Table 2. Mean (±SD) expression levels of the 23 genes detected among the 34 genes followed in this study in the healthy and treated DED mice corneas.
Table 3. Fold changes and t-test values (vs. DED untreated) for the 23 genes detected among the 34 genes followed in this study in the DED (± treatment) mice corneas. Fold changes calculated with real expression values. The t-test was performed on log10-transformed values of the raw data (not parametric). Note, to estimate a fold change for the gene not detected (ND, counts = 0), a copy number was arbitrarily set to one (1) for calculation purpose.
Table 4. Spearman correlation between CFS scores and gene expression levels for the untreated DED and DED with treatment groups for a total of 30 animals.