Advanced search
Publication Cover
Current Eye Research Volume 47, 2022 - Issue 2
Submit an article Journal homepage
1,237
Views
1
CrossRef citations to date
0
Altmetric
Retina

Effects of Acute Intracranial Pressure Changes on Optic Nerve Head Morphology in Humans and Pig Model

Sachin Kedara Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA;b Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USACorrespondence[email protected]
View further author information
,
Junfei Tongc Department of Mechanical Engineering, University of Nebraska, Lincoln, NE, USAView further author information
,
John Badera Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USAView further author information
,
Shane Havensa Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USAView further author information
,
Shan Fana Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USAView further author information
,
William Thorelld Department of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, USAView further author information
,
Carl Nelsonc Department of Mechanical Engineering, University of Nebraska, Lincoln, NE, USAView further author information
,
Linxia Guc Department of Mechanical Engineering, University of Nebraska, Lincoln, NE, USA;e Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL, USAView further author information
,
Robin Highf College of Public Health, University of Nebraska Medical Center, Omaha, NE, USAView further author information
,
Vikas Gulatia Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USAView further author information
&
Deepta Ghatea Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USAView further author information
 show all
Pages 304-311 | Received 24 Dec 2020, Accepted 28 Jun 2021, Published online: 12 Dec 2021

Figures & data

Figure 1. Anatomy of the optic nerve head as seen on optical coherence tomography imaging. ONSAS- Optic nerve subarachnoid space

Figure 1. Anatomy of the optic nerve head as seen on optical coherence tomography imaging. ONSAS- Optic nerve subarachnoid space

Figure 2. Theoretical framework for the interaction of pressure gradients across lamina cribrosa (CSF: cerebrospinal fluid; ONH: Optic nerve head)

Figure 2. Theoretical framework for the interaction of pressure gradients across lamina cribrosa (CSF: cerebrospinal fluid; ONH: Optic nerve head)

Table 1. Baseline data for the cohort of patients undergoing lumbar puncture

Figure 3. Optic nerve morphological parameters measured on OCT images (ALCD: Anterior lamina cribrosa depth; PLCD: posterior lamina cribrosa depth; BMOD: Bruch’s membrane opening diameter)

Figure 3. Optic nerve morphological parameters measured on OCT images (ALCD: Anterior lamina cribrosa depth; PLCD: posterior lamina cribrosa depth; BMOD: Bruch’s membrane opening diameter)

Table 2. Quality control analysis for the optic nerve head imaging using SD-OCT

Table 3. The effect on ophthalmic parameters of acute ICP lowering following lumbar puncture. Values depicted are mean (standard deviation)

Figure 4. Top panel: Slopes generated using linear effects model demonstrate a linear relationship between changes in ICP and changes in diastolic blood pressure (DBP), systolic blood pressure (SBP), and intraocular pressure. Lower panel: The effects of acute ICP changes on optic nerve head morphology are not significant. The variables on the horizontal and vertical are shown as mean centered values for each pig at each image meridian

Figure 4. Top panel: Slopes generated using linear effects model demonstrate a linear relationship between changes in ICP and changes in diastolic blood pressure (DBP), systolic blood pressure (SBP), and intraocular pressure. Lower panel: The effects of acute ICP changes on optic nerve head morphology are not significant. The variables on the horizontal and vertical are shown as mean centered values for each pig at each image meridian

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.