Analysis of Biomechanical Response After Corneal Crosslinking with Different Fluence Levels in Porcine Corneas

Figures & data

Table 1. Stress (kPa) at the strain of 6, 8, and 10%.

	Group 1 (20 J/cm^2)	Group 2 (15 J/cm^2)	Group 3 (10.8 J/cm^2)	Group 4 (5.4 J/cm^2)	Group 5 (control)
6%	116.9 ± 33.6	93.9 ± 20.6	97.8 ± 23.9	81.0 ± 23.5	59.9 ± 34.0
8%	193.9 ± 44.4	166.8 ± 25.9	166.7 ± 36.0	141.0 ± 32.2	103.6 ± 46.8
10%	284.5 ± 51.5	252.8 ± 32.1	246.0 ± 46.8	212.1 ± 39.1	162.0 ± 58.9

Figure 1. Young’s modulus at a strain of 10%. Group 1 = corneal crosslinking (CXL) with a fluence of 20 J/cm², group 2 = CXL with a fluence of 15 J/cm²; group 3 = CXL with a fluence of 10.8 J/cm²; group 4 = CXL with a fluence of 5.4 J/cm²; group 5 = control group untreated corneas.

Table 2. p-Values resulting from post-hoc Bonferroni adjusted analysis of variance (ANOVA) between stress (kPa) at the strain of 10% after CXL with different fluences.

	Group 1 (20 J/cm^2)	Group 2 (15 J/cm^2)	Group 3 (10.8 J/cm^2)	Group 4 (5.4 J/cm^2)	Group 5 (control)
Group 1 (20 J/cm^2)	x	0.475	0.210	<0.001	<0.001
Group 2 (15 J/cm^2)	0.475	x	1.000	0.129	<0.001
Group 3 (10.8 J/cm^2)	0.210	1.000	x	0.304	<0.001
Group 4 (5.4 J/cm^2)	<0.001	0.129	0.304	x	0.021
Group 5 (Control)	<0.001	<0.001	<0.001	0.021	x

Data availability statement

The data that support the findings of this study are available from the corresponding author, [IF], upon reasonable request.