Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and Hospital Episode Statistics

Figures & data

Table 1. Baseline characteristics of BT patients.

	All patients		Matched patients
	DAR	HES	DAR	HES
Mean age at BT1 (years)	43.5 ± 12.0 (n  =  83)Range 21–69	44.4 ± 12.4 (n  =  85)Range 21–74	42.6 ± 12.1 (n  =  59)Range 21–69	42.7 ± 12.0 (n  =  59)Range 21–69
Female (%)	71.1	74.1	78.0	78.0

Table 2. Baseline characteristics of BT patients compared with control (C) groups.

	DAR	DAR (matched cohort)	AIR2 trial	AIR trial	RISA trial
Mean age (years)	43.5 ± 12.0 (n^a  =  83)Range 21–69	42.6 ± 12.1 (n  =  59)Range 21–69	40.7 ± 11.9 (BT, n  =  190)40.6 ± 11.9 (C, n  =  98)	39.4 ± 11.2 (BT, n  =  55)41.7 ± 11.4 (C, n  =  54)	39.1 ± 13.0 (BT, n  =  15)42.1 ± 12.6 (C, n  =  17)
% female	71	78	57 (BT), 61 (C)	56 (BT), 57 (C)	60 (BT), 41(C)
Pre-bronch FEV1(% predicted)	70.2 ± 21.8 (n  =  65)Range: 18–109	70.7 ± 21.6 (n  =  51)Range 18–109	77.8 ± 15.7 (BT)79.7 ± 15.1 (C)	72.7 ± 10.4 (BT)76.1 ± 9.3 (C)	62.9 ± 12.2 (BT)66.4 ± 17.8 (C)
AQLQ score	3.74 ± 1.13 (n  =  48)Range 1.0–6.31	3.67 ± 1.11 (n  =  34)Range 1.58–6.31	4.30 ± 1.17 (BT)4.32 ± 1.21 (C)	5.6 ± 1.1 (BT)5.7 ± 0.9 (C)	3.96 ± 1.34 (BT)4.72 ± 1.06 (C)

^a n is the number of patients for whom data were available.

Table 3. Safety outcomes.

	All procedures		Matched procedures
	DAR	HES	DAR	HES	Combined^a
Procedures with any reported respiratory event (%;95% CI)	41/215 (19.1;14.0-25.0)	-	31/152 (20.4; 14.3-27.7)	-	-
Procedures with complications (%;95% CI)	16/215 (7.4; 4.3-11.8)	13/203 (6.4; 3.5-10.7)	13/152 (8.6; 4.6-14.2)	7/152 (4.6; 1.9-9.3)	17/152 (11.2; 6.7-17.3)
Procedures followed by readmission within 30 days:
a) for any cause (%;95% CI)	11/207 (5.3; 2.7-9.3)	28/203 (13.8; 9.4-19.3)	10/148 (6.8; 3.3-12.1)	25/152 (16.4; 10.9-23.3)	29/152 (19.1; 13.2-26.2)
b) for respiratory cause  AND emergency admission (%;95% CI)	11/207 (5.3; 2.7-9.3)	14/203 (6.9; 3.8-11.3)	10/148 (6.8; 3.3-12.1)	13/152 (8.6; 4.6-14.2)	18/152 (11.8; 7.2-18.1)
Procedures followed by A&E attendance within 30 days:
a) for any cause (%;95% CI)	1/207 (0.5; 0.0-2.7)	19/203 (9.4; 5.7-14.2)	1/148 (0.7; 0.0-3.7)	13/152 (8.6; 4.6-14.2)	13/152 (8.6; 4.6-14.2)
b) for respiratory cause AND not admitted (%;95% CI)	1/207 (0.5; 0.0-2.7)	2/203 (1.0; 0.1-3.5)	1/148 (0.7; 0.0-3.7)	1/152 (0.7; 0.0-3.6)	1/152 (0.7; 0.0-3.6)
Procedures followed by overnight stay (%;95% CI)	47/215 (21.9; 16.5-28.0)	92/194 (47.4; 40.2-54.7)	40/152 (26.3; 19.5-34.1)	63/147 (42.9; 34.7-51.3)	70/152 (46.1; 37.9-54.3)

^a Matched procedures with an event reported in either DAR or HES alone, or both.

Table 4. Matched cohort: numbers of procedures with procedural complications in DAR or HES alone, or both.

	DAR—Y	DAR—N	Total
HES—Y	3	4	7
HES—N	10	135	145
Total	13	139	152

Table 5. Matched cohort: numbers of procedures followed by emergency respiratory readmission within 30 days in DAR or HES alone, or both.

	DAR—Y	DAR—N	Total
HES—Y	5	8^a	13
HES—N	5	134	139
Total	10	142	152

^a 1 DAR case had missing data.

Table 6. Matched cohort: numbers of procedures followed by respiratory A&E attendance within 30 days (without hospital admission) in DAR or HES alone, or both.

	DAR—Y	DAR—N	Total
HES—Y	1	0	1
HES—N	0	151	151
Total	1	151	152