Complicating effects of obstructive sleep apnea syndrome on the severity of adult asthma

Figures & data

Table 1. Patient demographics.

No.	60
Sex (male/female)	12/48
Age	65.00 ± 13.38
BMI	26.54 ± 4.78
BA treatment step (1/2/3/4)	0/0/25/35
ICS (μg/day, budesonide equivalent)	1334 ± 570
FEV1 (L)	2.054 ± 0.767
%FEV1 (% of predicted)	104.05 ± 21.89
FEV1/FVC (%)	73.51 ± 11.41
FeNOvero (ppb)	31.6 ± 28.5
R5 (cmH2O/L/s)	4.34 ± 2.36
R20 (cmH2O/L/s)	3.46 ± 1.41
X5 (cmH2O/L/s)	–1.31 ± 2.02
Resonance frequency (Hz)	10.09 ± 5.07
ALX (cmH2O/L/s)	10.84 ± 19.0
AHI	19.33 ± 16.88
Rhintis	44
Laryngopharngeal reflux	19

Data are presented as means ± 1 SD. n = 60 except ICS (59), FeNO (n = 53) and FOT (n = 57). FEV1: forced expiratory volume in the first second. The fraction of exhaled nitric oxide; ICS: inhaled corticosteroid.

Table 2. Correlation between various parameters and AHI or lowest SpO₂ at PSG.

		AHI		Lowest SpO2
		r	p	r	p
BMI	26.54 ± 4.78	0.169	0.19	−0.16	0.22
FEV1 (L)	2.054 ± 0.767	0.77	0.55	0.015	0.91
%FEV1 (% of predicted)	104.05 ± 2 1.89	0.22	0.092	−0.064	0.62
FEV1/FVC (%)	73.51 ± 11.41	0.093	0.47	−0.018	0.89
FeNOvero (ppb)	31.6 ± 28.5	0.07	0.608	0.10	0.46
R5 (cmH2O/L/s)	4.34 ± 2.36	−0.075	0.58	−0.14	0.30
R20 (cmH2O/L/s)	3.46 ± 1.41	−0.12	0.37	−0.058	0.67
X5 (cmH2O/L/s)	−1.31 ± 2.02	−0.015	0.91	0.12	0.39
Resonance frequency (Hz)	10.09 ± 5.07	−0.04	0.77	−0.12	0.38
ALX (cmH2O/L/s)	10.84 ± 19.0	−0.013	0.92	−0.10	0.47

Data are presented as means ±1 SD. n = 60 for all comparisons, except FeNO (n = 53) and FOT (n = 57).

r: Pearson correlation among parameters.

Figure 1. Comparison of patient characteristics between low AHI and high AHI groups.

Figure 2. Comparison of level of asthma treatment between high and low AHI in the overweight group.

Table 3. Comparison of patient characteristics between low AHI and high AHI groups.

	AHI ＜ 15	15 ≦ AHI	p
BMI	26.02 ± 4.84	27.53 ± 4.503	0.17
FEV1 (L)	1.98 ± 0.74	2.20 ± 0.80	0.27
%FEV1 (% of predicted)	100.55 ± 22.48	110.42 ± 19.16	0.16
FEV1/FVC (%)	71.47 ± 11.87	77.30 ± 9.39	0.045
FeNOvero (ppb)	33.57 ± 31.24	27.19 ± 20.29	0.79
R5 (cmH2O/L/s)	4.41 ± 2.50	4.21 ± 2.04	0.97
R20 (cmH2O/L/s)	3.57 ± 1.45	3.23 ± 1.29	0.43
X5 (cmH2O/L/s)	−1.30 ± 1.92	−1.33 ± 2.22	0.98
Resonance frequency (Hz)	10.23 ± 5.08	9.79 ± 5.04	0.82
ALX (cmH2O/L/s)	9.37 ± 15.57	9.82 ± 22.82	0.81

Mann–Whitney U tests were used to obtain p values. Data are presented as means ±1 SD. n = 60 for all comparisons, except FeNO (n = 53) and FOT (n = 57).

Table 4. Relationship between rhinitis and AHI.

	AHI < 15	AHI ≥ 15
allergic rhinitis－	12	4
allergic rhinitis ＋	27	17

χ², p = 0.50; n = 60.