2,189
Views
13
CrossRef citations to date
0
Altmetric
Pharmacotherapy

Treatment patterns among non-active users of maintenance asthma medication in the United Kingdom: a retrospective cohort study in the Clinical Practice Research Datalink

, MBBS, MPH, PhD, DFPH, FRSPHORCID Icon, , MBBS, MSc, MBAORCID Icon, , MScORCID Icon, , MHSORCID Icon, , OBE, MSc, DipN, DipHVORCID Icon, , BPharm, PhDORCID Icon & , MB, BChir, MA, DRCOG, FRCGPORCID Icon show all
Pages 793-804 | Received 11 Sep 2019, Accepted 09 Feb 2020, Published online: 23 Feb 2020

Figures & data

Figure 1. Consort diagram.

Figure 1. Consort diagram.

Table 1. Baseline demographic and clinical characteristics.

Figure 2. Five most common treatment sequences by index asthma maintenance medication group.

Proportions were calculated using the total number of patients across all index therapies as the denominator (n = 55,293); durations above each arrow denote the mean time spent in a given treatment class by patients with that treatment sequence; total sequence durations may not sum to the same value due to rounding and leap years.

ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Figure 2. Five most common treatment sequences by index asthma maintenance medication group.Proportions were calculated using the total number of patients across all index therapies as the denominator (n = 55,293); durations above each arrow denote the mean time spent in a given treatment class by patients with that treatment sequence; total sequence durations may not sum to the same value due to rounding and leap years.ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Figure 3. Survival analysis of time to first change in therapy (days) by index asthma maintenance medication group.

For description of first event, see . Other included leukotriene receptor antagonists (LTRA) and methylxanthines. ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Figure 3. Survival analysis of time to first change in therapy (days) by index asthma maintenance medication group.For description of first event, see Table 2. Other included leukotriene receptor antagonists (LTRA) and methylxanthines. ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Table 2. Summary of time to first medication change and therapy change event by index treatment class.

Figure 4. Proportion of patients prescribed ≥ 4 SABD cannisters during baseline and follow-up by index asthma maintenance medication group.

Other included leukotriene receptor antagonists (LTRA) and methylxanthines.

ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Figure 4. Proportion of patients prescribed ≥ 4 SABD cannisters during baseline and follow-up by index asthma maintenance medication group.Other included leukotriene receptor antagonists (LTRA) and methylxanthines.ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Table 3. Asthma maintenance therapies prescribed during 2-year follow-up by index asthma maintenance medication group.

Figure 5. Proportion of patients who had RCP3Q review during follow-up by index asthma maintenance medication group.

Other included leukotriene receptor antagonists (LTRA) and methylxanthines

ICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist

Figure 5. Proportion of patients who had RCP3Q review during follow-up by index asthma maintenance medication group.Other included leukotriene receptor antagonists (LTRA) and methylxanthinesICS: inhaled corticosteroid; ICS/LABA: inhaled corticosteroid/long-acting beta2-agonist
Supplemental material

Supplemental Material

Download Zip (260 KB)

Availability of data and materials

Information on GSK’s data sharing commitments and requesting access can be found at: https://www.clinicalstudydatarequest.com