Characteristics of patients with frequent systemic corticosteroid bursts for asthma in real clinical practice: are there frequent “short bursts?”

Abstract

Objective

The data on intermittent systemic corticosteroid therapy for asthma exacerbation, clinically called a “short burst,” is limited. This study aimed to investigate the characteristics of patients with frequent systemic corticosteroid bursts for asthma in real clinical practice.

Methods

Consecutive patients who regularly visited our hospital for asthma treatment between January 2019 and December 2020 were reviewed. The number of systemic corticosteroid bursts during the past 1 year was collected, and those with frequent bursts (≥2 times/year) were defined as the Frequent group.

Results

Data on 236 patients were analyzed. Among them, 5.5% (95% confidence interval 3.2–9.2%) were in the Frequent group. In the Frequent group, 23% of patients had no unplanned visits, and 38% experienced at least one corticosteroid burst without visiting a physician (self-medication). One-third of patients did not undertake high-dose inhaled corticosteroid treatment, and three-fourths of patients did not undertake long-acting muscarinic antagonist treatment. Low pulmonary function and increased blood eosinophils were independently associated with the Frequent group (adjusted odds ratio = 0.73, 95% confidence interval 0.55–0.99, P = 0.039, per 10% predicted increase in a forced expiratory volume in 1 s; adjusted odds ratio = 1.15, 95% confidence interval 1.02–1.29, P = 0.025, per 100/μL increase in blood eosinophils).

Conclusions

There was a certain rate of frequent corticosteroid bursts in real clinical practice. It is important to determine the actual condition, as some patients experienced “hidden” frequent bursts and have the option to reinforce the treatment.

Acknowledgements

The authors thank the doctor’s assistants for the data collection. The authors also thank Enago (www.enago.jp) for the English language review.

Declaration of interest

All authors have completed the ICMJE uniform disclosure form. The authors have no conflict of interest.

Additional information

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.