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Journal of Asthma Volume 59, 2022 - Issue 6
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Genetics

A pilot study of differential gene expressions in patients with cough variant asthma and classic bronchial asthma

Guanghong Zhoua Department of Respiratory and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China;b Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, P. R. China;c North Sichuan Medical College, Nanchong, Sichuan, P. R. ChinaView further author information
, MD, MS,
Qingcui Zengb Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, P. R. China;d Department of Geriatric intensive care unit, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. ChinaView further author information
, MD,
Wei Weid Department of Geriatric intensive care unit, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China;e Department of Respiratory and Critical Care Medicine, Anyue County People’s Hospital, Anyue, Sichuan, P. R. ChinaView further author information
, MD,
Hong Tenga Department of Respiratory and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. ChinaView further author information
, MD,
Chuntao Liuf Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. ChinaView further author information
, MD, PhD,
Zhongwei Zhoua Department of Respiratory and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. ChinaView further author information
, MD,
Binmiao Liangf Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. ChinaView further author information
, MD, PhD &
Huaicong Longb Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, P. R. China;d Department of Geriatric intensive care unit, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. ChinaCorrespondence[email protected]
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, MD, PhD show all
Pages 1070-1078 | Received 21 Dec 2020, Accepted 10 Apr 2021, Published online: 14 May 2021

Figures & data

Table 1. List of primers used in real-time PCR for the detection of the 10 candidate genes.

Table 2. Characteristics of individuals in each group.

Figure 1. Heatmap of the groups. Gene expression heatmap of the groups. (A) Heatmap between the HC group and the CA group. (B) Heatmap between the HC group and the CVA group. (C) Heatmap between the CA group and the CVA group. Green indicates low expression, and red indicates high expression. Samples in group g1 (HC, healthy control): CHY1, LHC2, WC3, ZYX-8–31, ZGH-8–31. g2 (CA, classical asthma): HS4, ZXM6, HXF8, WFG7, XYQ5. g3 (CVA, cough variant asthma): LY9, CL10, XCY11, ZJ13, L12.

Figure 1. Heatmap of the groups. Gene expression heatmap of the groups. (A) Heatmap between the HC group and the CA group. (B) Heatmap between the HC group and the CVA group. (C) Heatmap between the CA group and the CVA group. Green indicates low expression, and red indicates high expression. Samples in group g1 (HC, healthy control): CHY1, LHC2, WC3, ZYX-8–31, ZGH-8–31. g2 (CA, classical asthma): HS4, ZXM6, HXF8, WFG7, XYQ5. g3 (CVA, cough variant asthma): LY9, CL10, XCY11, ZJ13, L12.

Figure 2. Top 30 GO enrichment terms between groups. (A) Top 30 GO enrichment terms between the HC group and the CA group, (B) Top 30 GO enrichment terms between the HC group and the CVA group, (C) Top 30 GO enrichment terms between the CA group and the CVA group. HC: healthy control group; CA: classical asthma group; CVA: cough variant asthma group.

Figure 2. Top 30 GO enrichment terms between groups. (A) Top 30 GO enrichment terms between the HC group and the CA group, (B) Top 30 GO enrichment terms between the HC group and the CVA group, (C) Top 30 GO enrichment terms between the CA group and the CVA group. HC: healthy control group; CA: classical asthma group; CVA: cough variant asthma group.

Figure 3. Changes of KEGG pathway of ‘asthma’ between the CA and the CVA group. Green represents downregulated genes. Light green represents the genes are present in this species. CA: classical asthma group; CVA: cough variant asthma group.

Figure 3. Changes of KEGG pathway of ‘asthma’ between the CA and the CVA group. Green represents downregulated genes. Light green represents the genes are present in this species. CA: classical asthma group; CVA: cough variant asthma group.

Table 3. Top 15 enriched pathways between the HC and CA groups.

Table 4. Top 15 enriched pathways between the HC and CVA groups.

Table 5. Top 15 enriched pathways between the CA and CVA groups.

Table 6. Comparison of the relative expression of candidate genes in groups.

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