The effects of different parity and delivery mode on wheezing disorders in the children—a retrospective cohort study in Fujian, China

Abstract

Background

The relationship between childbirth delivery methods and the risk of wheezing in children remains controversial. Few studies have explored it under different maternal conditions.

Objective

To explore the influence of childbirth delivery method on the onset of wheezing in children of different parity.

Methods

A total of 21716 patients were included in this retrospective observational study. Multivariable logistic regression was used to analyze the relationship between childbirth delivery method and wheezing in children under 18 years of age in Fujian Province.

Results

Wheezing differed statistically based on the child’s sex, age, season of onset, parity, jaundice history, and feeding patterns (P < 0.05). After adjusting for confounding factors, in cases of parity greater than two, the risk of wheezing in cesarean section deliveries was higher than that in vaginal deliveries (OR: 1.107; 95% CI 1.010–1.214). In girls with parity greater than two (OR: 1.179; 95% CI 1.003–1.387) and normal-weight infants with parity greater than two (OR: 1.106; 95% CI 1.003–1.220), the risk of wheezing in cesarean section deliveries was higher. The interaction term between the mode of childbirth and parity was significant in girls (P = 0.014).

Conclusion

The method of childbirth delivery and parity are related to the risk of wheezing and may be relevant to gender and birth weight. Parity and gender have synergistic effects on wheezing.

Acknowledgements

This study was performed following the Declaration of Helsinki. This human study was approved by the Ethics Committee of Fujian Provincial Maternity and Children’s Hospital—approval: 2020YJ175. The study’s clinical trial registration number is ChiCTR2000033019—registered with a medical records-based retrospective study for pediatric wheezing disease. Participant registration took place from Apr-2019 to Sep-2020.

Authors’ contributions

ZYB and LGH conceived of the study, participated in its design, and reviewed the manuscript. GHY, MC, and LHB designed the study, performed the data analysis, and drafted the manuscript. BM, ZHJ, WZQ, LW, LWJ, and XLB carried out the data collection and drafted part of the manuscript. All authors read and approved the final manuscript.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

The research work was supported by the Provincial-level special subsidy funds for health in Fujian Province of China (No: Fujian Finance Index [2020] 467).