Green synthesis of 1,7-bis(substituted phenyl)1,6-heptadiene-3,5-diones and their inhibition of human pathogenic bacteria

Abstract

Curcumin analogs are synthesized with solid support under the concept of green chemistry, i.e. in the absence of organic solvents or hazardous chemicals using silica-sulfuric acid under solvent free conditions. Their structures are established through infrared, NMR, and mass spectroscopy and elemental analysis. The antibacterial activities of the synthesized curcumin analogs are evaluated against three human pathogenic Gram negative bacteria, taking ciprofloxacin as standard compound. Most compounds exhibit some antibacterial activity, with an efficacy depending upon nature and position of the phenyl substituents.

Graphical Abstract

Keywords:

• Curcumin analogs
• green synthesis
• solid support
• silica-sulfuric acid
• antibacterial
• inhibition zones

Acknowledgments

Our immense and heartfelt thanks to our Professor Dr. Y. L. N. Murthy, Dept. of Organic Chemistry, Andhra University, Dr. Sai Devi, Assistant Professor, Dept. of Microbiology, Andhra Medical College, and Dr. Y. Nagendra Sastry, GITAM University for their constant support and guidance in the successful completion of this study.

Disclosure statement

No potential conflict of interest was reported by the author(s).